Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi.

Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi. J Leukoc Biol. 2016 Apr 21; Authors: Buffen K, Oosting M, Li Y, Kanneganti TD, Netea MG, Joosten LA Abstract We have previously demonstrated that inhibition of autophagy increased the ITALIC! Borrelia burgdorferiinduced innate cytokine production in vitro, but little is known regarding the effect of autophagy on in vivo models of ITALIC! Borreliainfection. Here, we showed that ATG7-deficient mice that were intra-articular injected with ITALIC! Borreliaspirochetes displayed increased joint swelling, cell influx, and enhanced interleukin-1β and interleukin-6 production by inflamed synovial tissue. Because both interleukin-1β and interleukin-6 are linked to the development of adaptive immune responses, we examine the function of autophagy on ITALIC! Borreliainduced adaptive immunity. Human peripheral blood mononuclear cells treated with autophagy inhibitors showed an increase in interleukin-17, interleukin-22, and interferon-γ production in response to exposure to ITALIC! Borrelia burgdorferi.Increased IL-17 production was dependent on IL-1β release but, interestingly, not on interleukin-23 production. In addition, cytokine quantitative trait loci in ATG9B modulate the ITALIC! Borreliainduced interleukin-17 production. Because high levels of IL-17 have been found in patients with confirmed, severe, chronic borreliosis, we propose that the modulation of ...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research