Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media (CSOM)

Conclusion Multidrug resistant strains of P. aeruginosa were more prevalent than those of S. aureus in ear discharges. Tobramycin and cloxacillin may be included in the formulatory antibiotic regimen to overcome bacterial infections in CSOM.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research

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Publication date: Available online 17 February 2020Source: Inorganica Chimica ActaAuthor(s): Priyaranjan Kumar, Ray J. Butcher, Ashis K. PatraAbstractHerein, we report physiochemical aspects, crystal structures, biological reactivity and interaction, DNA damage activity and preliminary antimicrobial properties of three metal complexes, [Co/Ni(dppz)2(sac)(H2O)]ClO4 [Co(II), 1; Ni(II), 2] and [Cu(dppz)2(sac)]ClO4 (3), where dppz is dipyrido[3,2-a:2′,3′-c]phenazine as potential photosensitizer and DNA intercalator and sac is artificial sweetener saccharin (o-sulfobenzimide). The solid-state structural analysis rev...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
In this study, UV photolysis was selected as an appropriate pretreatment technology for antibiotic-containing wastewater. It could decompose many kinds of antibiotics and was not inhibited by the coexisting organics in wastewater. The antibacterial activities of five kinds of antibiotics, which were eliminated with UV irradiation, exhibited a significantly positive correlation with their parent compound concentrations. The photodecomposition of the main functional groups in antibiotics contributed to the elimination of antibacterial activity. Defluorination was the main pathway to eliminate the antibacterial activity of an...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: Available online 15 February 2020Source: Journal of Hazardous MaterialsAuthor(s): Fisseha A Bezza, Shepherd M Tichapondwa, Evans MN ChirwaAbstractUniformly dispersed silver nanoparticles (AgNPs) with remarkable colloidal stability were synthesized using chemical reduction method in lipopeptide biosurfactant reverse micelles. Transmission Electron microscopy (TEM), Scanning electron microscopy (SEM) and UV–vis spectroscopy analysis exhibited monodisperse nanoparticles with spherical morphology of diameter of 21 ± 2. The lipopeptide stabilized AgNPs displayed remarkable antibacter...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
In this study, the effectiveness and safety of amphenmulin were further investigated. Amphenmulin showed excellent antibacterial activity against MRSA (minimal inhibitory concentration = 0.0156~8 µg/mL) and performed time-dependent growth inhibition and a concentration-dependent postantibiotic effect (PAE). Acute oral toxicity test in mice showed that amphenmulin was a practical non-toxic drug and possessed high security as a new drug with the 50% lethal dose (LD50) above 5000 mg/kg. The pharmacokinetic properties of amphenmulin were then measured. After intravenous administration, the elimination half-life (T1/2...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Authors: Becker K, Both A, Weißelberg S, Heilmann C, Rohde H Abstract Introduction: Compared to Staphylococcus aureus, coagulase-negative staphylococci (CoNS) are characterized by a lower capacity to cause acute, live-threatened infections. CoNS are, however, of ever increasing importance as pathogens causing infections in immunocompromised patients and after foreign-material implantation. Typically, antibiotics fail to cure foreign body-related infections and removal of the implanted device is inevitable.Areas covered: This review focuses on the emergence of CoNS species, their pathogenic potential in partic...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
CONCLUSIONS: Beyond methicillin resistance, we did not find phenotypic or genotypic factors associated with the poor outcome of S. aureus native arthritis. CC5 was the major CC, showing the higher genetic variability of MSSA versus MRSA. PMID: 32057526 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Graul AI, Pina P, Tracy M, Sorbera L Abstract Highlights of our annual review of new approvals and launches on global drug markets include the approval and launch of Trikafta, the most widely applicable treatment to date for cystic fibrosis; approval of the first Ebola vaccine for general (rather than emergency) use; the pilot rollout in three African countries of the world's first malaria vaccine; approval of a new treatment option for multidrug-resistant bacterial infections; and the approval and launch in China of the first new drug to treat Alzheimer's disease in more than a decade. Several new immune ...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
This study reports anti-virulence activity against S. aureus, including a MRSA clinical isolate, of naphto-γ-pyrones from Aspergillus welwitschiae mycelium, and the characterization of chemical constituents by LC-DAD and LC-MS. A remarkable decrease in biofilm formation, hemolysis and coagulation promoted by Staphylococcus aureus, important traits for bacterial pathogenicity, were observed. Furthermore, advantageous association with vancomycin resulted in significant protection against staphylococcal infection in Galleria mellonella model. These findings corroborate the importance of natural products as a source of n...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 23 January 2020Source: Journal of Hospital InfectionAuthor(s): M. Tracy, L. Ryan, H. Samarasekara, M. Leroi, A. Polkinghorne, J. Branley
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionThis study reports the first genome sequence of a multidrug-resistant M. hominis isolate in China. These data may help to understand the genomic features and antimicrobial resistance mechanisms of this pathogen.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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