Apr 22 Cardiology NewsApr 22 Cardiology News

The FDA’s decision on niacin and fenofibric acid, inappropriate carotid screening, same day discharge PCI, gender differences in testing for CAD, and obesity in adolescents are reviewed this week. theheart.org on Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news

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Conclusions Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Purpose We assessed resting central/peripheral blood pressure (BP), postexercise BP, and hemodynamic responses (stroke volume, cardiac output, and systemic vascular resistance) after acute exercise and 2 wk of aerobic training in lean and centrally obese men matched for BP. Methods Eight lean (body mass index 30 kg·m−2, visceral fat = 1471 ± 374 cm3) men performed six training sessions (3 d·wk−1 for 40 min at 65%–70% HRmax). Resting BP and hemodynamic measurements were obtained at baseline, after exercise for 60 min, and at 24 h and 48 h after the last training session. Results ...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients. PMID: 30326480 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2. Protein Cell. 2018 Oct 15;: Authors: Wang X, Gao H, Wu W, Xie E, Yu Y, He X, Li J, Zheng W, Wang X, Cao X, Meng Z, Chen L, Min J, Wang F Abstract Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal impo...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
No abstract available
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: LETTER TO THE EDITOR Source Type: research
ConclusionsOur data demonstrate that selective activation of ERβ exerts a tissue-specific activity which promotes a beneficial effect on whole body metabolic response to obesity.Graphical abstract
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Publication date: January–February 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 13, Issue 1Author(s): Sedigheh Nouhjah, Hajieh Shahbazian, Seyed Mahmoud Latifi, Reza Azizi Malamiri, Niloofar GhodratiAbstractAimsChild growth is one of the important health indicators in pediatric care. Few studies focused on the impact of prenatal exposure to gestational diabetes mellitus (GDM) on growth trajectories particular in early years of childhood. The aim of this study was identifying growth pattern of GDM exposed offspring's, comparison with new WHO child growth standards.Methods and ma...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In this study; 120 obese Saudi females with no diagnosed chronic diseases attending the Outpatient clinic at king Abdul-Aziz University hospital in Riyadh. Saudi Arabia, recruited randomly in period of 12 months. In this study, Serum levels of total Vitamin D were considered to be severe deficient if it was lower than 25 ng/mL, mild to moderate deficient if it was between 25 and 60 ng/mL and optimum level if it was 61-200 ng/mL. The results showed that; sun exposure was significantly affect and corelate with serum level of Vitamin D in the subjects. In addition, daily consumption of Vitamin D supplement was significantly a...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
This study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, and the cytotoxicity of the Cassia grandis nanodispersion (CgND).MethodsThe hypoglycemic effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, and conductivity, as well as the drug-loaded content, were monitored in shelf-live, along a year. The delivery profile was evaluated in simulated intestinal fluids at pH 6.5 and 7.4. The antioxidant effect was evaluated as DPPH and ABTS inhibition. The murine α-glucosidase inhibitory activity and the ...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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