Long-term Use of Statins and Risk of Renal Cell Carcinoma: A Population-based Case–Control Study

Conclusions Our study does not support an important chemopreventive effect of long-term statin use against RCC. The marginally increased and statistically insignificant risk estimates can readily be interpreted as a null finding, considering the lack of control for obesity and other lifestyle risk factors. Patient summary Previous studies have shown that the use of cholesterol-lowering drugs (statins) may protect against renal cancer. In a large study including all Danish renal cancers during an 11-yr period, we found no evidence of such an effect. Previous studies have reported conflicting results on the effect of statin use on renal cell carcinoma (RCC). Using information on all patients diagnosed with RCC in Denmark between 2002 and 2012, our study did not support a protective effect of long-term statin use on the development of RCC.
Source: European Urology - Category: Urology & Nephrology Source Type: research