Pathology of emphysematous reticulitis in cattle: report of two cases and comparative overview of similar or identical conditions

Abstract Inflammatory forestomach disorders other than those of viral, bacterial, mycotic, parasitic, chemical, or plant poisoning origin are uncommon in the bovine species. Spontaneous focal emphysematous lesions were grossly identified in the reticulum—the second part of the forestomach—of two adult Holstein-Friesian cattle (one 2-year-old steer, the other 3-year-old dairy cow). Both cattle, which appeared to be clinically normal without evidence of apparent forestomach dysfunction or other significant abnormalities on physical examination, were slaughtered conventionally for human consumption. At postmortem inspection of these two cattle, the reticulum wall showed focal spongy areas due to the occurrence of numerous minute gas bubbles (
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Conclusions Because the expression of copper tolerance genes is critical for the survival and virulence of fungal pathogens, pharmacological disruption of the function of copper tolerance genes would be predicted to have the following beneficial effects: (1) Induce fungal death: the loss of copper tolerance genes would lead to toxic levels of copper that would be expected to have fungistatic and/or fungicidal effects on the organism. (2) Enhance the activity of current antifungal drugs: the clinical efficacy of current antifungal drugs may be compromised by intrinsic or acquired resistance. Combination antifungal therapy ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, I found a novel pathogenicity-related protein of Salmonella, SEp22, an iron-chelating protein of MW 18.7 kDa, to cope with reactive-oxygen intermediates (ROIs) generated by activated macrophages pre-treated with lipopolysaccharides (LPS), one of the major components of Salmonella outer membrane. We also showed that Salmonella attacks macrophages by a novel mechanism through the induction of apoptosis with large amounts of LPS and protein synthesis inhibition, in addition to the well-known mechanisms of type-three secretion system (TTSS)-induced cell damage, including InvA, an attacking, virulent factor of Sa...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
ConclusionsAfter a single oral administration, the distribution and elimination of realgar in blood were slow, whereas it was rapidly absorbed and distributed in the liver, kidney and brain. Therefore, we recommend that realgar should not frequently used on a daily basis. Because the administration of a large dose of realgar did not display significant toxicity, we believe that the continuous administration of realgar for 30 days is safe in rats. In addition, hematology, biochemistry, and electrolyte levels and ECG should be monitored during realgar treatment. The accumulation and distribution of As species after 30 days o...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: The non-toxic plant C. filiformis absorbed toxic gelsemium alkaloids from its host, G. elegans, and led to gelsemium poisoning in our patients. Our study provides new insights into the toxicology of such plants. Benign parasitic plants may lead to potentially life-threatening poisoning if it parasitizes toxic hosts and absorbs their phytotoxins. The public awareness of risks associated with the use of these medicinal parasitic plants should be raised. PMID: 30273705 [PubMed - as supplied by publisher]
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
This study evaluated aromathecins, experimental inhibitors of mammalian topoisomerase IB, against Trypanosoma brucei African trypanosomes. The compounds had selectively toxic antiparasitic potency, had in situ poisoning activity against the phylogenetically unique topoisomerase in these parasites, and a representative compound intercalated into DNA with micromolar affinity. DNA intercalation and topoisomerase poisoning may contribute to the antitrypanosomal activity of aromathecins. PMID: 30104277 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Iowa and Illinois have recorded more than 100 cases of cyclosporiasis, which causes nausea and fatigue. McDonald ’ s has stopped selling salads at about 3,000 locations.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Food Contamination and Poisoning Lettuce Salads Parasites McDonald's Corporation Illinois Iowa Midwestern States (US) cyclosporiasis Source Type: news
Iowa and Illinois have recorded more than 100 cases of cyclosporiasis, which causes nausea and fatigue. McDonald ’ s has stopped selling salads at about 3,000 locations.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Food Contamination and Poisoning Lettuce Salads Parasites McDonald's Corporation Illinois Iowa Midwestern States (US) cyclosporiasis Source Type: news
While flu season is drawing to a close, transmission of germs can still lead to colds and serious respiratory diseases. In few places are individuals more exposed to a multitude of unique germs and germ carriers than during travel. Unlike some forms ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Source Type: blogs
In this study, we quantified U. seriolae in greater amberjack meats involved in food-poisoning episodes. U. seriolae DNA was detected in 26 samples out of 29 samples by means of quantitative real-time PCR(qRT-PCR). The major symptoms were diarrhea and vomiting within 12 hours after consumption. No seasonal trend in the outbreaks was apparent. The number of spores in samples with qRT-PCR-detected U. seriolae DNA ranged from 1.9×105 to 1.7×107 spores/g. However, no spores were detected in greater amberjack purchased from markets. These results indicate that U. seriolae was responsible for the outbreaks. The copy ...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - Category: Food Science Tags: Shokuhin Eiseigaku Zasshi Source Type: research
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