Plaudits due: how a search through soil led to a potent weapon against parasitic disease

Scientists William C. Campbell and Satoshi Ōmura were honoured with the Nobel Prize in Medicine for discovering a drug that has radically lowered incidences of parasitic diseases river blindness and lymphatic filariasis. Elly Earls reports.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
ConclusionKeen observation on the part of physicians is mandatory during the administration of ivermectin for quick recognition and prevention of this adverse drug reaction.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions/SignificanceWHO criteria have been met, therefore MDA in Bioko Island can be stopped. Three years of post-treatment surveillance should be implemented to identify any new occurrences of exposure or infection.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 235 and infectious diseases / animal theme. Readers can subscribe to FFFF RSS or subscribe to the FFFF weekly EMAIL Question 1: What tropical disease will give you Leopard or Lizard skin? + Reveal the Funtabulous Answer expand(document.getElementById('dde...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Frivolous Friday Five bull neck diphtheria Elephantiasis leonine facies leopard skin leprosy lion facies lizard skin lymphatic filariasis marasmus monkey facies onchocerciasis Source Type: blogs
The objective of this work was to update onchocerciasis elimination progress in Bioko Island, after 18 years of mass ivermectin intervention, and the general filariasis situation through a rapid and accurate molecular method. A cross-sectional study was conducted in Bioko Island from mid-January to mid-February 2014. A total of 543 subjects were included in the study. Whole blood and one skin snip (from lumbar regions) were analysed with a real time PCR assay. Two other skin biopsies were analysed by an expert microscopist. All positive samples were confirmed by sequencing. Traditional microscopic examination of the skin b...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract Approximately 100 million people suffer from filarial diseases including lymphatic filariasis (elephantiasis), onchocerciasis (river blindness) and loiasis. These diseases are amongst the most devastating of the neglected tropical diseases in terms of social and economic impact. Moreover, many infection-induced immune mechanisms in the host, their relationship to disease-related symptoms and the development of pathology within the site of infection remain unclear. To improve on current drug therapies or vaccines, further studies are necessary to decipher the mechanisms behind filaria-driven immune respons...
Source: International Journal for Parasitology - Category: Parasitology Authors: Tags: Int J Parasitol Source Type: research
This article is part HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to eliminate them. More than 1 billion people on the planet suffer from illnesses that the world pays little attention to. Neglected tropical diseases are a group of at least 18 diseases that primarily affect people living in poverty in tropical regions of the world and are virtually unknown elsewhere, according to the World Health Organization. These are diseases like river blindness, which has infected 18 million people worldwide and caused blindness in 270,000 people; or...
Source: Science - The Huffington Post - Category: Science Source Type: news
by Daniela K Schl üter, Martial L Ndeffo-Mbah, Innocent Takougang, Tony Ukety, Samuel Wanji, Alison P Galvani, Peter J Diggle Lymphatic Filariasis and Onchocerciasis (river blindness) constitute pressing public health issues in tropical regions. Global elimination programs, involving mass drug administration (MDA), have been launched by the World Health Organisation. Although the drugs used are generally well tolerated, individuals who are highly co-infected withLoa loa are at risk of experiencing serious adverse events. Highly infected individuals are more likely to be found in communities with high prevalence. An u...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The paper by C édric Chesnais and colleagues1 in The Lancet Infectious Diseases reports excess mortality in people infected with the filarial parasite Loa loa, especially in individuals with high microfilaria densities.1 The study followed more than 3000 individuals from several villages in Cameroon over a period of 15 years. Eight different filarial parasite species are considered to be human parasites, but only four are causative agents of neglected tropical diseases (Onchocerca volvulus causes river blindness; Wuchereria bancrofti, Brugia malayi, Brugia timori cause lymphatic filariasis).
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research
Publication date: Available online 11 June 2016 Source:International Journal for Parasitology: Parasites and Wildlife Author(s): Felix Bosch, Ralph Manzanell, Alexander Mathis Twenty-seven species of the genus Onchocerca (Nematoda; Filarioidea) can cause a vector-borne parasitic disease called onchocercosis. Most Onchocerca species infect wild and domestic ungulates or the dog, and one species causes river blindness in humans mainly in tropical Africa. The European red deer (Cervus e. elaphus) is host to four species, which are transmitted by blackflies (simuliids) or biting midges (ceratopogonids). Two species, Oncho...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
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