091 The role of Hmga2 translocation during skin squamous cell carcinoma development
High Mobility Group A2 (Hmga2) functions as an oncogene overexpressed in a variety of human malignant neoplasms, induced in epithelial-mesenchymal transition, and in association with squamous skin carcinoma stemness. However, little is known about the expression of Hmga2 in cutaneous epithelium and its role during skin non-melanoma tumor development. Here, we find that Hmga2 is expressed as membrane protein out of bulge region in normal skin tissue by immunofluorescence staining, as membrane/cytoplasm/nuclear protein in papilloma tissue, and as nuclear protein in the skin squamous carcinoma tissue.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Y. Li, K. Boland, K. Johnson, S. Lad, X. Pi, R.J. Morris Tags: Carcinogenesis & Cancer Genetics Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Dermatology | Epithelial Cancer | Genetics | Melanoma | Nonmelanoma Skin Cancer | Skin | Skin Cancer | Squamous Cell Carcinoma | Translocation