091 The role of Hmga2 translocation during skin squamous cell carcinoma development

High Mobility Group A2 (Hmga2) functions as an oncogene overexpressed in a variety of human malignant neoplasms, induced in epithelial-mesenchymal transition, and in association with squamous skin carcinoma stemness. However, little is known about the expression of Hmga2 in cutaneous epithelium and its role during skin non-melanoma tumor development. Here, we find that Hmga2 is expressed as membrane protein out of bulge region in normal skin tissue by immunofluorescence staining, as membrane/cytoplasm/nuclear protein in papilloma tissue, and as nuclear protein in the skin squamous carcinoma tissue.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis & Cancer Genetics Source Type: research