Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition versus AT1 receptor blockade alone

In conclusion, ARNI reduces proteinuria, glomerulosclerosis, and heart weight in diabetic TGR(mREN2)27 rats more strongly than ARB, and this occurs independently of BP.

Source: Clinical Science - April 18, 2016 Category: Biomedical Science Authors: Roksnoer, L. C. W., van Veghel, R., Clahsen-van Groningen, M. C., de Vries, R., Garrelds, I. M., Bhaggoe, U. M., van Gool, J. M. G., Friesema, E. C. H., Leijten, F. P. J., Hoorn, E. J., Danser, A. H. J., Batenburg, W. W. Tags: PublishAheadOfPrint Source Type: research