Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Conclusion
Our results identify novel roles for profilin as an important mediator of cardiomyocyte hypertrophy. We show that overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response.

Source: Cardiovascular Research - April 18, 2016 Category: Cardiology Authors: Kooij, V., Viswanathan, M. C., Lee, D. I., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E., Cammarato, A. Tags: Cardiac biology and remodelling Source Type: research