Reduction of dopamine D 2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

This study suggests that unlike to R-ketamine, esketamine can cause dopamine release in the striatum, and that its release might be associated with psychotomimetic effects of esketamine.

http://link.springer.com/10.1007/s00406-016-0692-7

Source: European Archives of Psychiatry and Clinical Neuroscience - April 17, 2016 Category: Neuroscience Source Type: research