Role of TLRs and DAMPs in allograft inflammation and transplant outcomes

Nature Reviews Nephrology 12, 281 (2016). doi:10.1038/nrneph.2016.41 Authors: Faouzi Braza, Sophie Brouard, Steve Chadban & Daniel R. Goldstein Graft inflammation impairs the induction of solid organ transplant tolerance and enhances acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced after organ transplantation could lead to novel therapeutics to improve transplant outcomes. In this Review we describe endogenous substances — damage-associated
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Review Source Type: research