ACROSCORE: A New and Simple Tool for Diagnosing AcromegalyACROSCORE: A New and Simple Tool for Diagnosing Acromegaly

A novel scoring tool has been developed that may play an important role in the diagnosis of this rare disease. Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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The objective of the present study was to determine the effectiveness of insulin analogs compared withhuman insulin in the treatment of pregnant women with diabetes througha systematic review withmeta-analysis. The search comprised the period since the inception of each database until July 2017, and the following databases were used:MEDLINE, CINAHL, EMBASE, ISIWeb of Science, LILACS, Scopus, SIGLE andGoogle Scholar.We have selected 29 original articles: 11 were randomized clinical trials and 18 were observational studies.We have explored data from 6,382 participants. All of the articles were classified as having an interme...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
The objective of this review was to understand the role of trace elements in the form of supplements in metabolic control of Type 2 Diabetes Mellitus (T2DM). A systematic research was performed following PRISMA recommendations. Although 3236 studies were identified, only 18 studies composed of nine animal studies and nine clinical studies were included in this review. The included trace elements were Chromium (Cr), Selenium (Se), Zinc (Zn) and Vanadium (V). The time, dose and type of supplement varied among the studies. Se, Cr, Zn and V improved glycemic profile and antioxidant status while Se, Cr and Zn affected lipid pro...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Authors: Alassaf A, Odeh R, Gharaibeh L, Ibrahim S, Ajlouni K Abstract Background: Adequate glycemic control in children with type 1 diabetes reduces the risk of future complications. Identifying factors affecting HbA1c is crucial to achieve adequate metabolic control. We aim to identify possible socioeconomic predictors of poor metabolic control in children with type 1 diabetes in Jordan; which resembles a developing country with limited resources. Methods: Medical charts were reviewed for patients attending the pediatric endocrine clinics in two major diabetes centers. HbA1c ≥ 7.5% (58 mmol/mol) was consid...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Publication date: May 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 5Author(s): Hiddo J L Heerspink, Josef Coresh, Ron T Gansevoort, Lesley A Inker
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: May 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 5Author(s): Kate V McIntosh
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: May 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 5Author(s):
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Abstract Acromegaly is a rare disease caused by excessive production of growth hormone (GH), typically by a pituitary tumour. The diagnosis is usually delayed, and patients frequently develop various complications that cause premature mortality. In patients with hypertension, heart failure, diabetes, and arthropathies that are not age-specific, attention should be paid to signs of acromegaly. Insulin-like growth factor 1 (IGF-1) assay should be used as a screening test whenever acromegaly is suspected. Further diagnostic investigations and treatment should be carried out at specialist centres. First-line treatment...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
In conclusion, acromegaly registries offer a global view of the disease with no “a priori” assumptions. This is of outmost importance, because of the large amount of data and the huge number of associated comorbidities. This will help to establish guidelines for management of this rare disease.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
CONCLUSION: This small, observational registry study showed a relevant success rate of initial pituitary surgery in patients with confirmed acromegaly. Initial tumour size and postoperative IGF-1 levels help to risk stratify patients regarding expected outcomes. In the case of disease persistence, a multimodal approach using drug and radiotherapy is mandatory. PMID: 30141524 [PubMed - in process]
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
In this study, we examine if the incidence of myocardial infarction (MI) and stroke differ from that of the general population.MethodsData from the German Acromegaly Registry in seven specialized endocrine centres were analysed (n  = 479, 56% female, 46 years old at diagnosis, 5549 person-years from diagnosis). Standardized incidence ratios (SIR) were calculated as compared to the general population.ResultsMI and stroke incidences were very close to those of the general population with an SIR (95% CI) of 0.89 (0.47 –1.52, p = 0.80) for MI and 1.17 (0.66–1.93, p =&thi...
Source: Pituitary - Category: Endocrinology Source Type: research
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