Safety of Tdap vaccine in pregnant women: an observational study

Objectives Actively recruit and intensively follow pregnant women receiving a dose of acellular pertussis vaccine for 4 weeks after vaccination. Design and settings A prospective observational study conducted in 2 New Zealand regions. Participants Women in their 28th–38th week of pregnancy, recruited from primary care and antenatal clinics at the time of Tdap administration. Telephone interviews were conducted at 48 h and 4 weeks postvaccination. Main outcomes measures Outcomes were injection site reactions, systemic symptoms and serious adverse events (SAEs). Where available, data have been classified and reported according to Brighton Collaboration definitions. Results 793 women participated with 27.9% receiving trivalent inactivated influenza vaccine concomitantly. 79% of participants reported mild or moderate pain and 2.6% severe pain. Any swelling was reported by 7.6%, induration by 12.0% (collected from 1 site only, n=326), and erythema by 5.8% of participants. Fever was reported by 17 (2.1%) participants, 14 of these occurred within 24 h. Headache, dizziness, nausea, myalgia or arthralgia was reported by
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Infectious diseases, Paediatrics Research Source Type: research

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Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Sandeep Kumar, Monika Nehra, Deepak Kedia, Neeraj Dilbaghi, K. Tankeshwar, Ki-Hyun KimAbstractBioimplant engineering aims to mature biological alternatives to restore, retain, or modify damaged tissues and/or the functionality of organs. Remarkable advancements in modern material technology have helped the diversity of materials for orthopaedic implant application. As such, nanomaterials can simulate the surface properties of natural tissues, especially with respect to surface topography, surface chemistry, surface energy, and ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yawara Eguchi, Keigo Enomoto, Takashi Sato, Atsuya Watanabe, Takayuki Sakai, Masaki Norimoto, Masami Yoneyama, Yasuchika Aoki, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Miyako Suzuki, Kazuhide Inage, Yasuhiro Shiga, Naoya Hirosawa, Masahiro Inoue, Masao Koda, Takeo FuruyaAbstractThere is no imaging modality to quantitatively evaluate compressed cervical nerve roots in cervical radiculopathy. Here we sought to evaluate the usefulness of simultaneous apparent T2 mapping and neurogra...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 13 September 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): GQ Carvalho, M Pereira-Santos, LD Marcon, ID Louro, MCG Peluzio, DB SantosAbstractThere is a lack of studies about polymorphisms in FADS genes in pregnant women. We aimed to verify the interaction between three FADS gene polymorphisms (rs174561; rs174575; rs3834458) and dietary α-linolenic acid (ALA) or linoleic/α-linolenic acid ratio (LA/ALA) and plasma concentrations of omega-3 (n-3) PUFAs in pregnant women. Of the 250 women evaluated, the homozygous for the rs174561 and rs3834458 minor...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
Authors: Zhou NB, Wang KG, Fu ZJ Abstract The combination of morphine and ketamine is considered safe and efficacious in many patients. However, a considerable number of immunomodulatory effects have been reported to be produced by both morphine and ketamine. The aim of the present study was to assess the direct effect of morphine and a low dose of ketamine on the T cells of patients with refractory cancer pain in vitro. Venous blood was obtained from patients with refractory cancer pain and peripheral blood mononuclear cells were isolated using the Ficoll-Hypaque density gradient method. Anti-CD3 beads were used t...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In this study, the safety, efficacy, and advantages of Q-PTP and single-pulse laser mode of 1064-nm QSNY in the treatment of melasma were compared. Twelve healthy women were enrolled in this split-face study. Q-PTP and single-pulse laser mode of 1064-nm QSNY were applied to the treatment side and the control side, respectively. Physician's global assessment, patients' self-assessment and the modified melasma area and severity index (mMASI) scores were used to quantify pigmentation changes. Side effects were recorded. Mean mMASI scores were decreased significantly at the 4th and 12th-week follow-up visit compared to the bas...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 13 September 2019Source: The Veterinary JournalAuthor(s): C. Muller, M. Enomoto, A. Buono, J.M. Steiner, B.D.X. LascellesAbstractOsteoarthritis (OA) is a debilitating disease in dogs. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat OA; however, many dogs do not obtain adequate pain relief with an NSAID alone. This pilot study evaluated the systemic anti-inflammatory and mobility enhancing effects of an eggshell membrane-based nutritional supplement in dogs with OA-associated pain and mobility impairment. Twenty-seven dogs with OA-associated pain were enrolled int...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Conclusions: Some normotensive IgA nephropathy patients with mild proteinuria had impaired renal function at diagnosis. Ischemic sclerosis and fibrous crescent were the main pathological features in these patients. Patients in the crescent group had a worse outcome than patients in the ischemic sclerosis group. PMID: 31517550 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
In conclusion, the agonistic anti-TLR4 mAb induces potent CD8 T-cell-dependent antitumour immunity and an inflammatory response of lesser magnitude than does LPS. The agonistic anti-TLR4 mAb has potential as an adjuvant for use in vaccines against cancer. PMID: 31515801 [PubMed - in process]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research
We describe a novel type of high-affinity monoclonal antibody, that: a) targets specific trans-membrane receptor structures of harmful or redundant cells; b) is equipped with lipophilic and/or hydrophobic fragments that prevent physiological water flow inside ion channels. Therefore, we achieve an artificial dewetting transition inside receptor cavities, that causes discontinuity within transmembrane ionic flows, channel blockage, and subsequent damage of morbid cells. As an example, we describe dewetting monoclonal antibodies that target the M2 channel of the Influenza A virus: they might prevent water from entering pores...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 13 September 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Philip R. Baldwin, Dmitry LyumkisAbstractVirtually all single-particle cryo-EM experiments currently suffer from specimen adherence to the air-water interface, leading to a non-uniform distribution in the set of projection views. Whereas it is well accepted that uniform projection distributions can lead to high-resolution reconstructions, non-uniform (anisotropic) distributions can negatively affect map quality, elongate structural features, and in some cases, prohibit interpretation altogether. Although some ...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
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