A Rare Side Effect of GnRH Agonist Treatment in Precoccious Puberty: Pseudotumor Cerebri.

We presented a girl had precocious puberty treated with triptorelin acetate who developed pseudotumor cerebri after 4th dose. She had headaches and her blood pressure detected > 99 percentile. There were no causes underlying of hypertension such as cardiac, renal or endocrine. Neurological examination was normal except bilateral papilledema. Cranial magnetic resonance imaging was normal. Cerebrospinal fluid (CSF) opening pressure was detected elevated. Triptorelin therapy was ceased and CSF pressure back to normal. We observed pseudotumor cerebri after the puberte precocious treatment, for the first time ever seen in childhood. PMID: 27087351 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research