Dync1h1 Mutation Causes Proprioceptive Sensory Neuron Loss and Impaired Retrograde Axonal Transport of Dorsal Root Ganglion Neurons.

CONCLUSION: The Swl/Swl mutation of Dync1h1 gene led to embryonic mal-development and lethality, whereas the Swl/+ DRG neurons demonstrated deficient retrograde transport in dynein-driven cargos and excessive apoptosis during mid- to late-developmental stages. The underlying mechanism of the mutation may not be due to impaired homodimerization of DYNC1H1. PMID: 27080913 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27080913?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - April 14, 2016 Category: Neuroscience Authors: Zhao J, Wang Y, Xu H, Fu Y, Qian T, Bo D, Lu YX, Xiong Y, Wan J, Zhang X, Dong Q, Chen XJ Tags: CNS Neurosci Ther Source Type: research