The pain of prebiotics?

Here’s a question I hear on occasion: “I started the prebiotic fibers but I experienced a lot of bloating and abdominal discomfort and had to stop. Maybe they’re not for me.” As the Wheat Belly conversation is taken further into the mainstream population via the Wheat Belly 10-Day Grain Detox, I am hearing this more and more. Giving up too soon because of encountering a problem without understanding why is a sure way to booby-trap your return to health. Should you encounter problems such as bloating or discomfort with your prebiotic regimen, it is due to dysbiosis, disrupted bowel flora from prior eating habits and other factors. In other words, your previous diet of wheat, grains, and sugars, along with chlorinated/fluoridated drinking water, prescription antibiotics, herbicides and pesticides in food, etc. changed the composition of bowel flora, perhaps even allowing unhealthy species to ascend up the small intestine, occasionally as high as the duodenum and stomach (“small intestinal bacterial overgrowth,” or SIBO). Undesirable species such as E. coli, Enterobacter, and various Clostridia species proliferate and muscle out desirable species such as Lactobacillus. This can happen with green bananas, raw white potatoes, inulin, FOS, galactooligosacchrides, or any other form of prebiotic fiber. Dysbiosis at the start of your program is common. Even by lax criteria, 35% of people without abdominal symptoms can start with dysbiosis. Compared ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle bowel flora cholesterol dysbiosis health hypertension Inflammation prebiotic fibers resistant starch Weight Loss Source Type: blogs

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CONCLUSION: One copy number of GSTM1 and GSTT1 presented a higher frequency among carrier genes, but the CNV of GSTM1 and GSTT1 was not associated with HNC risk. PMID: 30526121 [PubMed - as supplied by publisher]
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Check-Cap is getting one step closer to having its capsule-based screening method for colorectal cancer on the U.S. market. The Isfiya, Israel-based company has received FDA conditional approval for an IDE to initiate a pilot study of the C-Scan capsule. FDA’s conditional approval of the IDE requires Check-Cap to provide additional information to the agency and the company may begin enrolling patients immediately upon approval by the study site's Institutional Review Board (IRB). The trial will consist of up to 45 patients and it will be a single-arm study. Patients who are enrolled will be those conside...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Implants Source Type: news
Source: BMJ News - Category: General Medicine Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Authors: Park HJ, Shin KC, Yoou SK, Kang M, Gon Kim J, Jun Sung D, Yu W, Lee Y, Hea Kim S, Min Bae Y, Park SW Abstract Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequence for arteries are unclear. Here, we examined the hypothesis that hydrogen peroxide (H2O2) regulates membrane potential (Em) by altering Na+ influx through cation channels, which conse...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Wang S, Miao Z, Yang Q, Wang Y, Zhang J Abstract Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis. The efficacy of MSC-based therapi...
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
Conclusion: We think this rare case could promote a better understanding of the dynamic nature of the central nervous system and the peripheral nervous system within intradural space. PMID: 30533275 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Aiming to achieve longer progression-free survival in cases of GS, we recommend resecting all portions of the mass as much as possible, so named en bloc resection, and then refer the patients for appropriate and timely chemoradiotherapy. PMID: 30533274 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: The challenging nature of these injuries requires extensive workup prior to surgical decision-making in order to minimize potential complications. PMID: 30533268 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusions: The combination of ViewSite and brain spatulas provides wide and adequate operative fields to observe the interface between lesions and normal tissue, and to prevent brain injury from excessive retraction pressure on the brain derived from repositioning of the ViewSite. Postoperative 3D volumetric analysis shows minimal damage to normal brain tissue. This report may provide new insight into the use of the ViewSite tubular retractor. PMID: 30533267 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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