Study: Chemo for Childhood Cancer Affects Male Survivors’ Fertility More Than Females’

By Stacy Simon RESOURCES: Preserving fertility in boys and teens with cancerPreserving fertility in girls and teens with cancer A study by researchers from leading cancer centers across the US has found that modern chemotherapy treatments have only a small impact on the ability of female childhood and adolescent cancer survivors to have children when they grow up. However, male survivors are more likely to have fertility problems. An estimated 400,000 survivors of childhood and adolescent cancer are living in the US today. However, therapies to treat their cancer can affect their reproductive health when they become adults, making it harder for them to have their own children. One way the medical community has responded to this problem is to lower the intensity of radiation treatments, and rely more on chemotherapy instead. Researchers from the Fred Hutchinson Cancer Research Center in Seattle and colleagues set out to study how much newer chemotherapy drugs affects childhood cancer survivors’ ability to have children. They looked at data from the Childhood Cancer Survivor Study, which tracks survivors of childhood cancer who were treated in the US and Canada between 1970 and 1999. The study looked at 10,938 childhood cancer survivors who were treated with 14 different commonly prescribed chemotherapy drugs and compared the number of pregnancies and children they eventually had with 3,949 of their brothers and sisters. The study focused on survivors who were treat...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Cancer in Adolescents Childhood Cancer Source Type: news

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Authors: Carroll K, Mesman J, McLeod H, Boughey J, Keeney G, Habermann E Abstract Utilising frozen section technologies, Mayo Clinic has one of the lowest reoperation rates for breast lumpectomy in the United States. The research reported on sought to understand the successful teamwork between the Breast Surgery Team and the Frozen Section Laboratory at Mayo Clinic. Researchers worked collaboratively with healthcare staff from breast surgery and the frozen section pathology laboratory to identify communication styles and strategies that contribute to the timely and accurate intraoperative evaluation of breast cance...
Source: Journal of Interprofessional Care - Category: Health Management Tags: J Interprof Care Source Type: research
ConclusionsNIV showed a significant protective effect for intubation in immunosuppressed patients (cancer and transplants) and in patients with APE/CAP. However, the benefits of NIV for other etiologies are not clear and more trials are needed to prove these effects.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
A new study shows a drug targeting the immune system could help women with an aggressive type of breast cancer. The results were announced at a conference in Europe and could change the way women are treated. Dr. Jon LaPook reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): Ryuji Yamaguchi, Lydia Lartigue, Guy PerkinsAbstractRegulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development of the hematopoietic system, for sustaining cell survival during generation of various cell types, in eliminating cells with dual identities such as CD4/CD8 double-positive cells1,2, for sustaining cells during the rapid clonal expansion phase3, as well as eliminating cells during the contraction phase4. The anti-apoptotic protein Mcl-1 is necessar...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): Joseph T. Madak, Armand Bankhead, Christine R. Cuthbertson, Hollis D. Showalter, Nouri NeamatiAbstractIdentified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived microenvironment. Rapidly growing cells depend on sufficient concentrations of nucleotides to sustain proliferation. One enzyme essential for the de novo biosynthesis of pyrimidine-based nucleotides is dihydroorotate dehydrogenase (DHODH), a known t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
This study highlighted the impact of each gum ingredient on the quality of the MCGs and demonstrated the feasibility of preparing chewing gums with up to 50% drug loading.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionMiR-21 suppressed the Hippo signaling pathway and promoted the progression of LAD through targeting KIBRA.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionApplication of cytostatic drugs in combination with apoptogenic plant extracts induced significant changes in transcriptome-wide mRNA microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects on neuronal functions associated with mild cognitive impairments in cancer chemotherapy.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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