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Study: Chemo for Childhood Cancer Affects Male Survivors’ Fertility More Than Females’

By Stacy Simon RESOURCES: Preserving fertility in boys and teens with cancerPreserving fertility in girls and teens with cancer A study by researchers from leading cancer centers across the US has found that modern chemotherapy treatments have only a small impact on the ability of female childhood and adolescent cancer survivors to have children when they grow up. However, male survivors are more likely to have fertility problems. An estimated 400,000 survivors of childhood and adolescent cancer are living in the US today. However, therapies to treat their cancer can affect their reproductive health when they become adults, making it harder for them to have their own children. One way the medical community has responded to this problem is to lower the intensity of radiation treatments, and rely more on chemotherapy instead. Researchers from the Fred Hutchinson Cancer Research Center in Seattle and colleagues set out to study how much newer chemotherapy drugs affects childhood cancer survivors’ ability to have children. They looked at data from the Childhood Cancer Survivor Study, which tracks survivors of childhood cancer who were treated in the US and Canada between 1970 and 1999. The study looked at 10,938 childhood cancer survivors who were treated with 14 different commonly prescribed chemotherapy drugs and compared the number of pregnancies and children they eventually had with 3,949 of their brothers and sisters. The study focused on survivors who were treat...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Cancer in Adolescents Childhood Cancer Source Type: news

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Authors: Yılmaz Susluer S, Kayabasi C, Ozmen Yelken B, Asik A, Celik D, Balci Okcanoglu T, Serin Senger S, Biray Avci C, Kose S, Gunduz C Abstract Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in cancer development. The role of lncRNAs in hepatitis B virus (HBV) infection is not well understood. Here we analyzed the expression of 135 lncRNAs in plasm...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Abstract Objective: Fecal immunochemical tests (FITs) for hemoglobin in stool are increasingly used for colorectal cancer screening. Reported sensitivities and specificities have strongly varied between studies, but it is unclear to what extent such variation reflects differences between tests or between study population characteristics. We aimed to evaluate the key parameters of FIT performance for detecting advanced neoplasia (AN) according to sex and age. Methods: Sex- and age-specific sensitivity, specificity, positive predictive values (PPVs) and negative predictive values (NPVs) for detecting AN of a qu...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research
CONCLUSION: TACE combined with partial hepatic segment thermal ablation is a safe and effective treatment for liver cancer patients, especially for those with more advanced disease. PMID: 29671661 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Applied this cycle and got rejected by every school. I had 3 interviews. Major: Neuroscience Minor: Chemistry, Public Health Country/state of residence: NC Cumulative GPA: 3.66 (currently 3.71) Science GPA: 3.49- got a C freshman year in math class (currently 3.51) Upward grade trend: 3.4 freshman year -> 3.95 senior year MCAT Scores: 130/129/130/128 Total: 517 Employment: TA for biochemistry- 10 hours a week Research: Research in cancer biology lab (paid)- 500 hours no publications or... What to do during a Gap Year
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Authors: Akatsuka S, Li GH, Toyokuni S Abstract Evolution of the species and carcinogenesis are similar in that genomic alterations are the key events. Oxidative stress derived from various etiologies is one of the major causes of carcinogenesis by inducing mutations in the genome. Persistent oxidative stress in the renal proximal tubules through Fenton reaction catalyzed by ferric nitrilotriacetate (Fe-NTA) generates renal cell carcinoma (RCC) in mice and rats. Here, in order to observe the species difference in oxidative stress-induced carcinogenesis and to obtain an insight regarding the characteristics of each ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Jasiewicz B, Sierakowska A, Jankowski W, Hoffmann M, Piorońska W, Górnicka A, Bielawska A, Bielawski K, Mrówczyńska L Abstract A series of new di- and polyamine-caffeine analogues were synthesized and characterized by NMR, FT-IR and MS spectroscopic methods. To access stability of the investigated caffeine analogues Molecular Dynamic simulations were performed in NAMD 2.9 assuming CHARMM36 force field. To evaluate the antioxidant capacity of new compounds, three different antioxidant assays were used, namely 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH•) scavenging activity, ferro...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
We describe our experience with the use of tubular retractors for accessing these deep-seated lesions. Fifty consecutive patients operated on for an intra-axial brain tumor (both biopsies and resection) from January 2016 to December 2017 by a single surgeon using tubular retractors with exoscopic visualization were prospectively identified and included in this consecutive case series. 35 patients (70%) underwent surgical resection and 15 (30%) underwent excisional biopsy for tumors located a median [interquartile range (IQR)] distance of 5.4 [4.5-6.1] cm below the cortical surface within the thalamus and/or basal ganglia i...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Source: Cancer Letters - Category: Cancer & Oncology Source Type: research
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and are poised to capture antigen, migrate to draining lymphoid organs, and postmaturation process. Recent evidences have suggested that tumor microenvironment has an effect on DCs by inactivating various components of the immune system responsible for tumor clearance, eventually leading to tumorigenesis. This inactivation is owed to the epigenetic modifications [ie, microRNA (miRNA)] at the posttranscriptional level, thus regulating the differentiation patterns and functional behavior of DCs. Thus, need of the hour is to develop protoco...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Review Article Source Type: research
The chemokine MIP3α (CCL20) binds to CCR6 on immature dendritic cells. Vaccines fusing MIP3α to gp100 have been shown to be effective in therapeutically reducing melanoma tumor burden and prolonging survival in a mouse model. Other studies have provided evidence that interleukin-10 (IL-10) neutralizing antibodies (αIL-10) enhance immunologic melanoma therapies by modulating the tolerogenic tumor microenvironment. In the current study, we have utilized the B16F10 syngeneic mouse melanoma model to demonstrate for the first time that a therapy neutralizing IL-10 enhances the antitumor efficacy of a MIP3&alph...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Basic Studies Source Type: research
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