cGAS-STING do it again: pivotal role in RNase H2 genetic disease

RNase H2 is a susceptibility gene for the Aicardi–Goutières syndrome (AGS), a genetic auto-inflammatory disease. Mackenzie and colleagues now report a tractable mouse model for the disease, implicating the cGAS-STING pathway.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology News [amp ] Views Source Type: research

Related Links:

This study underscores the capacity of human DC to discriminate between live and inactivated S. aureus and, further, indicates that DC may represent a valuable experimental setting to test different inactivation methods with regard to the retention of S. aureus immunoregulatory properties. These and further insights may be useful for the development of novel therapeutic and prophylactic anti-S. aureus vaccine strategies.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In recent years, I’ve encountered a growing number of parents in my therapy practice who come to me fearing that their child has oppositional defiant disorder (ODD). According to the American Psychiatric Association, the primary signs of ODD are angry and irritable mood, argumentative and defiant behavior, and vindictiveness. Often these parents will share that a teacher or doctor told them their child may have ODD, and that when they looked up the condition online, they recognized some of the symptoms in their child’s behavior. As a parent myself, the worry and confusion on my clients’ faces and, in the...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Children and Teens Parenting Stigma Students Child Development difficult child Oppositional Defiant Disorder Source Type: blogs
The feeling of abandonment can span through all types of relationships and in this episode, we focus on friendships. Have you ever had a close friend abandon you or have you ever exited a friendship without notice? The emotions and actions surrounding the abandonment of friends can be complex and hurtful, but they are very real and can hurt deeply.  In this episode, Jackie recounts friendships that were very important to her and how she’s handling the loss of them. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who live...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Family Friends General Grief and Loss Not Crazy Podcast Relationships Source Type: blogs
Twenty-six years after the arrival of “killer bees” in Arizona, the entire state with the exception of high elevations in the north is populated with this bee variety and 11 people have died at the scene of massive bee attacks.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
ConclusionsNew clinical aspect of diffuse alveolar hemorrhage is first reported to be associated with SAVI. Unsatisfactory therapeutic effects of tofacitinib are observed in this study and further evaluations are needed.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Toxoplasma gondii is an important neurotropic pathogen that establishes latent infections in humans that can cause toxoplasmosis in immunocompromised individuals. It replicates inside host cells and has developed several strategies to manipulate host immune responses. However, the cytoplasmic pathogen-sensing pathway that detects T. gondii is not well-characterized. Here, we found that cyclic GMP-AMP synthase (cGAS), a sensor of foreign dsDNA, is required for activation of anti-T. gondii immune signaling in a mouse model. We also found that mice deficient in STING (Stinggt/gt mice) are much more susceptible to T. gondii in...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
Toxoplasma gondii is an obligate protozoan parasite that naturally infects all mammals, where it alters the host environment to establish chronic infection. Wang and colleagues uncover a new role for the T. gondii protein GRA15 in inducing an anti-parasite response via the interferon stimulator STING. This parasite-driven host defense limits Toxoplasma replication while maintaining host survival, creating an ideal niche for the establishment of latency.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Highlights Source Type: research
When someone suggests you try being grateful when you failed an exam, lost your job, lost a loved one, are getting divorced, or are experiencing some other kind of awful, you probably want to punch that person in the face. (Hold on. Let me step aside.) But practicing gratitude during a difficult time can genuinely help. In 2009, I distinctly remember sitting around the table with my family, before or after my dad’s funeral, and all of us cracking up. I can’t remember why. But I can remember that it was the best kind of laughter—full body, sides hurting, faces contorted, uncontrollable, can’t-catch-y...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Books General Habits Holiday Coping Inspiration & Hope Mental Health and Wellness Self-Help Stress Success & Achievement Gratitude Source Type: blogs
Questions and controversies regarding venom immunotherapy (VIT) remain. It is important to recognize risk factors for severe sting anaphylaxis that guide the recommendation for testing, epinephrine injectors, and VIT. Premedication, rush VIT, and omalizumab are successful in overcoming recurrent systemic reactions to VIT. A maintenance dose is adequate in children, but higher doses are needed in high-risk patients. The consensus on risk of β-blockers and angiotensin-converting enzyme inhibitors in patients on VIT has shifted to the belief that risk is small. The decision to stop VIT after 5 years rests on known r...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
People who experience unexplained bug bites may wonder if they have fleas or bed bugs in the home. In this article, learn how to identify flea and bed bug bites, and what to do after discovering them.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Bites and Stings Source Type: news
More News: Allergy & Immunology | Genetics | Insect Bites & Stings | Molecular Biology