cGAS-STING do it again: pivotal role in RNase H2 genetic disease

RNase H2 is a susceptibility gene for the Aicardi–Goutières syndrome (AGS), a genetic auto-inflammatory disease. Mackenzie and colleagues now report a tractable mouse model for the disease, implicating the cGAS-STING pathway.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology News [amp ] Views Source Type: research

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Publication date: Available online 7 October 2020Source: CellAuthor(s): Chien-Hsiung Yu, Sophia Davidson, Cassandra R. Harapas, James B. Hilton, Michael J. Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R. Balka, Dale J. Calleja, Fiona Moghaddas, Erya Ni, Catriona A. McLean, Andre L. Samson, Shiraz Tyebji, Christopher J. Tonkin, Christopher R. Bye, Bradley J. Turner
Source: Cell - Category: Cytology Source Type: research
BED BUG bites are usually painless and hard to distinguish from other insect bites. If you spot symptoms in these four areas of the body it may indicate you've been bitten by bed bugs, however.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
TUESDAY, Oct. 6, 2020 -- The sting of fire ants can be painful and even deadly -- and the threat rises during fall across the southeastern United States. At this time of year, fire ants move to warm surfaces such as concrete slabs or asphalt roads,...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most frequently mutated genes in human cancer. We sought to develop rational combination therapy to potentiate the efficacy of immune checkpoint blockade in ARID1A-deficient tumors. In a proteomic analysis of a data set from The Cancer Genomic Atlas, we found enhanced expression of Chk2, a DNA damage checkpoint kinase, in ARID1A-mutated/deficient tumors. Surprisingly, we found that ARID1A targets the nonchromatin substrate Chk2 for ubiquitination. Loss of ARID1A increased the Chk2 level through modulating autoubiquitination of the E3-ligase RNF8...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ml;nstedt K Abstract A survey on 5115 beekeepers and 121 patients treated with bee venom by an apitherapy clinic in the Hubei province, the epicenter of COVID-19 in China, reported that none of the beekeepers developed symptoms associated with COVID-19, the new and devastating pandemic. The hypothesis that immunity to bee venom could have a preventive effect was expressed and the authors of the Chinese survey suggested that the next step should be animal experiments on monkeys. We believed that before starting such studies, a second independent survey should verify the findings and define the hypothesis more clear...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research
Abstract Maintaining mitochondrial health is essential for the survival and function of eukaryotic organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore mitochondrial network homeostasis, remove damaged or toxic proteins, and eliminate damaged organelles via selective autophagy of mitochondria, a process termed mitophagy. Failure of these quality control pathways is implicated in the pathogenesis of Parkinson's disease and other neurodegenerative diseases. Impairment of mitochondrial quality control has been demonstrated to activate innate immune pathways, including inflammasome-med...
Source: Annual Review of Cell and Developmental Biology - Category: Cytology Authors: Tags: Annu Rev Cell Dev Biol Source Type: research
AbstractNeuroinflammation has been shown to exacerbate ischemic brain injury, and is considered as a prime target for the development of stroke therapies.Clinacanthus nutans Lindau (C. nutans) is widely used in traditional medicine for treating insect bites, viral infection and cancer, due largely to its anti-oxidative and anti-inflammatory properties. Recently, we reported that an ethanol extract from the leaf ofC. nutans could protect the brain against ischemia-triggered neuronal death and infarction. In order to further understand the molecular mechanism(s) for its beneficial effects, two experimental paradigms, namely,...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
Conclusion: Collectively, we elucidated that the HDAC3-p65-cGAS-STING pathway is involved in the development of I/R-induced neuroinflammation, identifying a new therapeutic avenue for the treatment of ischemic stroke.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Condition:   Scorpion Stings Intervention:   Other: CBC Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the role of STING in B cell receptor (BCR) signaling remains unclear. We generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM, Igα, and Igβ via SEL1L/HRD1-mediated ER-associated degradation (ERAD). B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated STING. When...
Source: Cellular and Molecular Immunology - Category: Molecular Biology Authors: Tags: Cell Mol Immunol Source Type: research
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