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Madison’s story: Speaking up for autism

Madison Marilla had reached her breaking point. Starting at a new school after a cross-country move from California to Massachusetts isn’t easy for any eighth grader, but Madison wasn’t just any middle school student. She was diagnosed with autism at age 2. “No one understood my autism, obsessive-compulsive disorder (OCD) or attention-deficit hyperactivity disorder (ADHD).” Madison says. “Kids would push me, steal my things, trip me in the hall, memorize my locker combination.” Madison started feeling very negative. After speaking with her mentor, she decided the kids in her class might be able to understand her better if they were more aware of her autism. Jess, Madison’s mentor, gave her courage and a voice. “She changed me forever. She was always there for me and she always supported me.” Becoming an autism advocate “I stood in front of my class, and I said, ‘I was diagnosed with autism in 1999.’ I said, ‘It’s OK to be different.’” Although Madison’s classmates got the message, she knew there was more work to do. She set up an autism awareness table at her middle school to spread the message that not only is it OK to be different — it’s a good thing. When she reached high school, the table transformed into an autism awareness club with more than 50 members. When Channel 7 got wind up of the club, Madison was featured in a Class Act profile. Madison&r...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories Teen Health attention deficit hyperactivity disorder autism Department of Neurology Dr. Robert Wolff obsessive-compulsive disorder Source Type: news

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Conclusions Urgent research questions to further clarify the underlying pathophysiological and structural alterations are further outlined to bring this promising technique to the clinic. PMID: 28971725 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
Participants will learn practical strategies for accurately assessing various psychiatric causes of moodiness/irritability in childhood ADHD, including comorbid autism spectrum disorder (Dr. McLaren), anxiety and obsessive-compulsive disorder (Dr. Spaniardi), PTSD (Dr. Daviss), and disruptive behavioral disorders, including oppositional defiant, conduct, and disruptive mood dysregulation disorders (Dr. Blader). Participants will also learn potentially effective strategies for pharmacological and psychosocial treatments of such mood and behavioral problems in children with ADHD.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Clinical Perspectives 52 Source Type: research
CONCLUSIONS: Trial designs as well as results were heterogeneous and thus comparability was limited. Available data support the hypothesis that glutamatergic agents are of potential value in the treatment of compulsivity/impulsivity in children and adolescents. Based on the data reviewed, memantine and N-acetylcysteine suggest the best risk-benefit profile for future trials. Riluzole should primarily be further investigated in adults. Clinical research of this nature is a key element of the TACTICS Consortium project funded by the European Union (FP7). PMID: 28922069 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie - Category: Child Development Tags: Z Kinder Jugendpsychiatr Psychother Source Type: research
Duchenne muscular dystrophy (DMD) has a high incidence of learning and behavioural problems and comorbidity with neurodevelopmental disorders such as autism-spectrum disorders, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and dyslexia. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across healthy human brain development, using transcriptomic data from Allen Human Brain and BrainSpan atlases.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Conclusion: The findings show that profiles based on neuropsychiatric symptoms can be distinguished within a population-based sample of school-aged children scoring high on obsessive-compulsive symptoms. These profiles may be useful in establishing patterns of symptom course during development. Longitudinal follow-up is necessary to ascertain whether at a later age these subgroups still differ in their symptom profile and neuropsychiatric trajectory.
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Original Articles Source Type: research
An international team led by researchers from UCLA and Massachusetts General Hospital has identified the first definitive genes associated with Tourette syndrome, giving scientists a long-sought foothold on the biology of the disease.The report in the June 21 issue of Neuron describes the discovery of rare mutations — either deletions or duplications of genetic material — in two neurodevelopmental genes, NRXN1 and CNTN6, in people with Tourette syndrome, a disorder characterized by multiple chronic, involuntary motor and vocal tics.“This is a first, key step in understanding the role of these genes in the...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
AbstractTourette syndrome (TS) often presents with other comorbid conditions in clinical settings. The most common comorbidities are obsessive-compulsive disorder or obsessive-compulsive behaviors, attention deficit hyperactivity disorder, learning disabilities, autism, mood and anxiety disorders, and personality disorders. Comorbid disorders and coexistent psychopathologies are often associated with impaired functioning, more severe course, and poorer long-term outcome. The overall presentation of TS with and without comorbidities can be significantly different and comorbid neuropsychiatric conditions may also change with...
Source: Current Developmental Disorders Reports - Category: Child Development Source Type: research
Authors: Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, King RA, Tischfield JA, Heiman GA, Hoekstra PJ, Dietrich A Abstract Genetic studies in Tourette syndro...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New research Source Type: research
This study: 1) examined ASD symptom rates in participants with TS and 2) characterized the relationships between ASD symptom patterns and TS, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research
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