Cytotoxicity, Genotoxicity and Antioxidant Activity of Extracts from Capsicum spp.

Extracts of different genotypes of Capsicum (C. annuum L., C. baccatum L., C. chinense Jacq., C. frutescens L. and C. praetermissum) were investigated for total phenolics, flavonoids, capsaicinoids contents and antioxidant activity objectifying to determine the relations between these bioactive compounds and the antioxidant capacity and also examine its cytotoxic and genotoxic potential. Capsicum praetermissum showed the highest total antioxidant activity and the highest concentrations of phenolic compounds and flavonoids. For C. annuum and C. frutescens the antioxidant activity was significant and the levels of phenolic compounds and flavonoids intermediate, while C. baccatum demonstrated the lowest antioxidant activity independent of significant levels of these compounds. Capsicum chinense showed the lowest level of total phenols and flavonoids despite expressive antioxidant activity. The determination of capsaicinoid content revealed higher levels of capsaicin and dihydrocapsaicin for extracts of C. praetermissum, intermediate levels to C. baccatum, C. chinense and C. frutescens, whereas, the C. annuum showed the lowest levels of capsaicinoids, typical of these ornamental genotype. The extracts of C. praetermissum and C. baccatum exhibited low cytotoxic potential compared to other genotypes. The genotoxic potential was variable between analyzed genotypes, with C. praetermissum presenting the lowest rates. All species showed a dose-effect relationship dependent of extract c...
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Publication date: Available online 20 October 2018Source: Urology Case ReportsAuthor(s): Y. Ayari
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 October 2018Source: Urology Case ReportsAuthor(s): Vincent Khor, LIE Kwok Ying
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
In this report, we looked at opioid medication use following discharge after radical prostatectomy. We found that 77% of opioid pain medication prescribed was unused, with 84% of patients using less than half of their prescription. Prescribing more opioids was associated with greater use; only 9% of patients appropriately disposed of leftover medication.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Authors: Voulgaris A, Nena E, Steiropoulos P PMID: 30338831 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Fisichella R, Benfatto S, Berretta S PMID: 30338830 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Pintaudi B, Di Vieste G, Corrado F, Lucisano G, Giunta L, D'Anna R, Di Benedetto A Abstract OBJECTIVE: Myo-inositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. No data are available about its effect on glucose variability. The aim of this study was to evaluate the effects of a supplementation of myo-inositol on glucose variability in women with GDM. PATIENTS AND METHODS: Myo-inositol effect on glucose variability was studied in a pilot case-control study involving 12 consecutive pregnant women (median age 34 years, 25.0% insulin...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: MiR-124 down-regulation was associated with renal cancer cell OS-RC-2 invasion enhancement. Over-expression of miR-124 attenuated OS-RC-2 cell invasion by down-regulating STAT3 and MMP-9. PMID: 30338828 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Cyclosporine protects HK-2 cells from inflammatory injury via regulating mTOR pathway. PMID: 30338826 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Golino M, Spera FR, Manfredonia L, De Vita A, Di Franco A, Lamendola P, Villano A, Melita V, Mencarelli E, Lanza GA, Crea F Abstract OBJECTIVE: About one-third of patients undergoing percutaneous coronary interventions (PCIs) for flow-limiting coronary stenosis continue to develop signs of myocardial ischemia (MI) during exercise stress test [EST], despite successful coronary revascularization. Coronary microvascular dysfunction is a likely major cause of the persistence of EST-induced MI in these patients. PATIENTS AND METHODS: We studied 15 patients (14 men, age 67±5 years) fulfilling the foll...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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