Obesity and male infertility: A global health problem

(Bentham Science Publishers) Infertility is a silent problem that obese men have to face. This is a health issue that deserves attention from policymakers and the media.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Abstract Context: Obese women usually need larger doses of FSH for ovarian stimulation, resulting in poor outcomes; however, the mechanism is still unclear. Objective: To investigate the molecular regulation of FSH receptor (FSHR) expression associated with obesity. Design: Case-control study to improve IVF outcomes. Patients: Eighty-two obese and 457 overweight women undergoing IVF and 1,790 age-matched controls with normal weight from our reproductive medicine center. Intervention: No special. Main Outcome Measures: FSHR expression was decreased in parallel with BMI, while the oestradiol...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Obesity stands as one of the greatest healthcare challenges of the 21st century. Obesity in reproductive-age men is ever more frequent and is reaching upsetting levels. At the same time, fertility has taken an inverse direction and is decreasing, leading to an increased demand for fertility treatments. In half of infertile couples, there is a male factor alone or combined with a female factor. Furthermore, male fertility parameters such as sperm count and concentration went on a downward spiral during the last few decades and are now approaching the minimum levels established to achieve successful fertilization. Hence, the...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Review Articles Source Type: research
Conclusions: Loss-of-function mutations of DLK1 are a definitive cause of familial CPP. The high prevalence of metabolic alterations in adult women who experienced CPP due to DLK1 defects suggests that this antiadipogenic factor represents a novel link between reproduction and metabolism. PMID: 30462238 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Authors: Macut D, Milutinović DV, Rašić-Marković A, Nestorov J, Bjekić-Macut J, Stanojlović O Abstract Over the last decade, huge achievements have been made in the fields of neurophysiology, molecular endocrinology, and biochemistry, as well as in the successful translation of clinical research into diseases into clinical practice. As regards female reproduction, most of the advances made in this area were achieved in gonadal axis regulation, regulation of behavior through sex steroids, reproductive genetics, preservation of ovarian reproductive function, steroid profiling, and metabolic and overall re...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Evaluating the association of TNF α promoter haplotype with its serum levels and the risk of PCOS: A case control study. Cytokine. 2018 Nov 12;: Authors: Bhatnager R, Jalthuria J, Sehrawat R, Nanda S, Dang AS Abstract Poly cystic ovary syndrome is the major cause of anovulatory infertility. TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS. Present case control study was carried on 400 women of ag...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
igi L Abstract It is universally accepted that lifestyle interventions are the first step towards a good overall, reproductive and sexual health. Cessation of unhealthy habits, such as tobacco, alcohol and drug use, poor nutrition and sedentary behavior, is suggested in order to preserve/improve fertility in humans. However, the possible risks of physical exercise per se or sports on male fertility are less known. Being "fit" does not only improve the sense of well-being, but also has beneficial effects on general health: in fact physical exercise is by all means a low-cost, high-efficacy method for prev...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder in women, leading to infertility. However, there is no general agreement concerning how to diagnose and treat PCOS. The Rotterdam consensus statement from the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine, the Chinese diagnostic criteria and consensus statement, and the clinical practice guideline from the Endocrine Society in the USA are widely recognized. Guidance has been provided for clinical practice based on a comparative analysis of the above three practice guideli...
Source: J Zhejiang Univ Sci ... - Category: Science Authors: Tags: J Zhejiang Univ Sci B Source Type: research
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
(MedPage Today) -- News and commentary from the endocrinology world
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news
[Guardian] Experts have raised fresh alarm that more men could become infertile due to huge drop in sperm quality caused by rising pollution, junk food, obesity, smoking, exposure to plastics and lack of exercise.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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