Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk

The role of the different factors associated with fatty liver is still poorly defined. We evaluated the relationships between liver fat content (LF) and metabolic, inflammatory and nutritional factors in a homogeneous cohort of individuals at high cardio-metabolic risk.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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Publication date: Available online 12 December 2019Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Rodolfo Quintana Castro, Isaac Aguirre Maldonado, Ida Soto Rodríguez, Rosa A. Deschamps Lago, Peter Grube Pagola, Yolanda K. Urbina de Larrea, Victoria E. Juárez Rivera, Luis E. Ramos Manuel, Alfonso Alexander AguileraAbstractObesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD). The pathogenesis between obesity and hepatic steatosis is partially known, but could involve differentiated or tissue...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Publication date: Available online 13 December 2019Source: Food ChemistryAuthor(s): Yifan Bao, Jianbo Xiao, Zebin Weng, Xinyi Lu, Xinchun Shen, Fang WangAbstractThe increasing incidence of metabolic syndrome requires more functional food products with low cost and excellent effects to assist treatment. The crude extract of Moringa oleifera Lam. showed excellent hypoglycemic activity. The current study was designed to investigate the effects and mechanism of niazirin, a bioactive component from Moringa oleifera Lam. seed, on diabetic metabolic syndrome. C57BL/6J mice were treated daily with 5 mL/kg/body weight (BW) of salin...
Source: Food Chemistry - Category: Food Science Source Type: research
This study aimed to assess the association between serum ferritin (SF) and NAFLD among middle-aged and elderly Chinese with normal weight. METHODS AND STUDY DESIGN: A total of 2029 Chinese adults aged 35-70 years with normal weight were involved in this cross-sectional study. General information, lifestyle factors and laboratory characteristics were collected. The concentrations of serum alanine aminotransferase (ALT) and SF were recorded. Receiver operating characteristic (ROC) was applied to assess predictive performance of SF for NAFLD. Logistic regression analysis was conducted to evaluate the associations of SF w...
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
(Natural News) Extracts from the medicinal mushroom Cordyceps militaris can potentially be used to prevent — even reverse — nonalcoholic fatty liver disease (NAFLD), one of the most prevalent forms of liver disease among American adults. In a study published in the Journal of Medicinal Food, researchers from South Korea investigated whether C. militaris can regulate lipogenesis in the...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Ischemia reperfusion injury (IRI) has been shown to increase the risk of tumor recurrence after liver surgery. Also, nonalcoholic fatty liver disease (NAFLD) is associated with increased HCC recurrence. ALOX12...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD spectrum of disease involves progression from steatosis (NAFL), to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Despite clinical and public health significance, current FDA approved therapies for NAFLD are lacking in part due to insufficient understanding of pathogenic mechanisms driving disease progression. The etiology of NAFLD is multifactorial. The induction of both systemic and tissue inflammation consequential of skewed immune cell metabo...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Cardiometabolic diseases encompass those affecting the heart and vasculature as well as other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver disease. These diseases tend to have common risk factors, one of which is impaired adiponectin action. This may be due to reduced bioavailability of the hormone or resistance to its effects on target tissues. A strong negative correlation between adiponectin levels and cardiometabolic diseases has been well-documented and research shown that adiponectin has cardioprotective, insulin sensitizing and direct beneficial metabolic effects. Thus, the...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Mirhafez SR, Rezai A, Dehabeh M, Nobakht M Gh BF, Bidkhori M, Sahebkar A, Hariri M Abstract Scientists proposed that curcumin could be used for treatment of non-alcoholic fatty liver disease (NAFLD). In this article, we aimed to identify the effect of curcumin on NAFLD improvement. Fifty patients with NAFLD, were divided into two groups in this randomized, double-blind, and controlled clinical trial. Patients in the curcumin group received 250 mg/day of phytosomal curcumin, while those in the control group received 250 mg/day of placebo for duration of eight weeks. Anthropometric measurements an...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Condition:   NAFLD Interventions:   Drug: Saroglitazar;   Drug: Vitamin E;   Drug: Combination drug;   Behavioral: Lifestyle Changes Sponsor:   Asian Institute of Gastroenterology, India Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractNon-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression of inflammation for non-alcoholic steatohepatitis (NASH). NAFLD is described as a multifactorial complication due to the genetic predisposition, metabolic functions, inflammatory, gut microbiota (GM), and environmental factors. The GM dysregulation among these factors is correlated to NAFLD development. In recent decades, advanced microbial profiling methods are continu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
More News: Cardiology | Cardiovascular | Fatty Liver Disease (FLD) | Heart | Insulin | Liver | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Urology & Nephrology