Cetuximab in Human Papillomavirus-Positive Oropharynx Carcinoma EDITORIALS

Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: EDITORIALS Source Type: research

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ard J Abstract Background: Incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising rapidly in many western countries due to Human papillomavirus (HPV) and tobacco smoking, with a considerable overlap. Immunotherapy directed at the PD1/PD-L1 axis have shown promise in head and neck cancer and other cancer types. PD-L1 expression may indicate a poorer prognosis, and at the same time indicate a possible benefit of anti-PD-L1 immunotherapeutic agents. The primary aim of this study was to establish the prognostic effect of PD-L1 expression after primary curative radiotherapy alone.Material and methods: A c...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
CONCLUSION: In this French series with lot of heavy smokers, under half of carcinomas are HPV induced. Clinicopathological features and survival data associated with HPV infection are the same as those classically described in literature. PMID: 32081547 [PubMed - as supplied by publisher]
Source: Annales de Pathologie - Category: Pathology Authors: Tags: Ann Pathol Source Type: research
Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Tr...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Study protocol Source Type: research
Squamous cell carcinoma of the head and neck (SCCHN) is the seventh most common malignancy and is responsible for 3.7% of cancer deaths worldwide [1]. The main risk factors are alcohol and tobacco. The human papillomavirus (HPV) is another risk factor for oropharyngeal cancer (OPC) and its incidence is rising [2].The 5-year survival rate of SCCHN is still poor, ranging from 25% - 60% depending on tumor staging and site [3]. Most patients present with locally-advanced disease, but despite multimodal treatment including chemoradiation or surgery followed by (chemo)radiation, more than 50% of patients will relapse.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Hot Topic Source Type: research
Conditions:   HPV Positive Oropharyngeal Squamous Cell Carcinoma;   HIV-1-infection;   HPV Infection Interventions:   Biological: 9 valent human papillomavirus vaccine (Types 6, 11, 16, 18, 31, 33, 45, 52, 58);   Other: Saline Placebo Sponsors:   Weill Medical College of Cornell University;   H. Lee Moffitt Cancer Center and Research Institute;   University of Sao Paulo;   University of Puerto Rico;   Mexican National Institute of Public Health;   National Cancer In...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Over the past three decades, the incidence of oropharyngeal squamous cell carcinoma has increased, primarily related to the spread of human papillomavirus. Treatment has always been preferentially unimodal (surgery or radiotherapy) for early stage disease and multimodal (surgery with adjuvant therapy or concomitant chemoradiotherapy) for advanced stages. Recently, the surgical approach has gained renewed interest due to the morbidity of non-surgical treatments and also to technical innovations. We have coined the term 3Des (3D exoscope surgery) to describe the use of the 3D Vitom Exoscope System for transoral surgery of or...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Patients with squamous cell carcinoma of the oropharynx are generally treated with (chemo) radiation. Patients with oropharyngeal cancer (OPC) have better survival than patients with squamous cell carcinoma of other head and neck subsites, especially when related to human papillomavirus (HPV). However, radiotherapy results in a substantial percentage of survivors suffering from significant treatment-related side-effects. Late radiation-induced side-effects are mostly irreversible and may even be progressive, and particularly xerostomia and dysphagia affect health-related quality of life (HRQoL). As the ri...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
AbstractIn oropharyngeal squamous cell carcinoma (OPSCC), the relationships between immune responses, carcinogens, and prognoses are not clarified yet. Here, we retrospectively reviewed the pathology samples of 46 OPSCC patients, and used p16 to determine their human papillomavirus (HPV) status. The Cancer Genome Atlas (TCGA) database was also analyzed for further comparison. The immunofluorescence staining of proinflammatory cytokines showed that high interferon gamma (IFN γ; T helper 1; Th1), low interleukin 4 (IL4; T helper 2; Th2), low thymic stromal lymphopoietin (TSLP; Th2), and low transforming growth factor b...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
CONCLUSION: The 8th edition TNM staging system provides better OS stratification in oropharyngeal cancer after definitive CRT compared with the 7th edition. Other clinical variables, such as complete response at 3 months, alcohol and tobacco smoking, should also be considered in future classifications as they provide additional risk stratification information in both HPV-positive and HPV-negative disease. PMID: 31981964 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
We appreciate the authors ’ interest in our paper.1 However, for the readers, I want to emphasize that the main finding of the paper is the prognostic importance of radiologic extranodal extension (rENE) for human papillomavirus (HPV)-mediated (HPV+) oropharyngeal carcinoma (OPC). The authors’ concern regarding the term “HPV-mediated,” and the HPV testing algorithm, are interesting companion points.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
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