Combination Anti-CTLA-4 and Anti-RANKL in Metastatic Melanoma DIAGNOSIS IN ONCOLOGY

Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Combined Modality, Translational Oncology, Melanoma, Immunology/Immunobiology DIAGNOSIS IN ONCOLOGY Source Type: research

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ConclusionsA small subset of PSPD patients may experience response after an initial progression. Assessment of the current strategy for immune ‐related response evaluations may require further attention.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conditions:   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma;   Follicular Lymphoma;   Marginal Zone Lymphoma;   Mantle Cell Lymphoma;   Diffuse Large B Cell Lymphoma;   Advanced Solid Tumor;   Non-small Cell Lung Cancer;   Metastatic Melanoma Interventions:   Drug: BGB-10188;   Drug: Zanubrutinib;   Drug: Tislelizumab Sponsor:   BeiGene Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionDespite malignant disease, overall survival of patients after metastasectomy for pancreatic metastasis is acceptable. Better survival appears to be associated with the primary tumor entity. Further research should focus on molecular markers to elucidate the mechanisms of pancreatic metastasis to choose the suitable therapeutic approach for the individual patient.
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
AbstractImmune checkpoint inhibitors (ICIs), monoclonal antibodies to cytotoxic T-lymphocyte-associated protein 4, programmed cell death 1 or its ligand PD-L1 are rapidly changing the treatment landscape and prognosis of many cancer types. Following their initial approval in melanoma in 2011, ICIs are now approved in many other cancers. Despite the long-term, durable response that can be noted with ICIs, the majority of patients do not respond to ICIs and some of the initial responders develop relapsed disease during their treatment course. In order to improve the response rate to ICIs, an understanding of the mechanisms o...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractIdentification of barriers to seeking health care for a concerning mole found during skin self-examination (SSE) by women educated during screening mammography. In this sequential mixed methods research, interviews with women who found a concerning mole and did not have health-care follow-up were analyzed and a survey was created. One year after SSE education, barriers to having health care for a self-identified concerning mole were assessed. The electronic medical records for all participants, who received education, were reviewed to ascertain who received health care related to a concerning mole or a screening ma...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Publication date: 1 June 2020Source: Inorganica Chimica Acta, Volume 506Author(s): Hassan H. Hammud, Ulrich Kortz, Saurav Bhattacharya, Sally Demirdjian, Essa Hariri, Samih Isber, Eun Sang Choi, Babak Mirtamizdoust, Mohamad Mroueh, Costantine F. DaherAbstractThe dinuclear complex Bis[(µ-azido)-chloro-(1,10-phenanthroline)-copper(II)] (1) was synthesized, and characterized by X-ray. Complex (1) crystallizes in the monoclinic system, it consists of centrosymmetric [CuCl(phen)µ-N3]2 dimers bridged by azide groups. The phenanthroline ligand, chloride ion, and ƞ-N of equatorial bridging azide ligand are coplanar an...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): Andrea BUSNELLI, Amerigo VITAGLIANO, Laura MENSI, Stefano ACERBONI, Alessandro BULFONI, Francesca FILIPPI, Edgardo SOMIGLIANAAbstractSeveral epidemiological studies investigated the effects of cancer therapies on fertility. However, conflicting data have been reported.The present systematic review and meta-analysis aims to determine the chances of childbirth in women survived from different types of cancer.We systematically searched Pubmed, MEDLINE, Embase and Scopus, from database inception to July 17, 2019, for published ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Authors: Kamm A, Przychodzeń P, Kuban-Jankowska A, Marino Gammazza A, Cappello F, Daca A, Żmijewski MA, Woźniak M, Górska-Ponikowska M Abstract Melanoma is an aggressive type of skin cancer with one of the highest mortality rates. Notably, its incidence in the last few decades has increased faster than any other cancer. Therefore, searching for novel anticancer therapies is of great clinical importance. In the present study, we investigated the anticancer potential of 2-methoxyestradiol, potent chemotherapeutic, in the A375 melanoma cellular model. In order to furthermore evaluate the anticancer efficacy ...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
ConclusionA plasma vemurafenibCss,min threshold of 50  mg/L is strongly associated with survival outcomes in patients with advanced melanoma. This new threshold needs to be validated prospectively in future studies.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro. Braz J Med Biol Res. 2020;53(3):e8876 Authors: Da-Costa RC, Vieira IL, Hunger A, Tamura RE, Strauss BE Abstract The immune stimulatory and anti-neoplastic functions of type I interferon have long been applied for the treatment of melanoma. However, the systemic application of high levels of this recombinant protein is often met with toxicity. An approach that provides localized, yet transient, production of type I interferon may overcome this limitation. We propose that the use of mesenchymal stem ...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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