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Why We Need New Antibiotics More Than Ever

This article was produced in partnership with Northeastern University and was originally published on Footnote, a website that brings academic research and ideas to a broader audience. A year ago, a group of scientists led by Dr. Kim Lewis, Director of the Antimicrobial Discovery Center at Northeastern University, announced a major breakthrough. They had identified a new antibiotic, teixobactin, capable of destroying several kinds of bacteria, including antibiotic-resistant strains of tuberculosis and staph (i.e. MRSA).1 Antibiotics are so familiar to us that the discovery of a new one may not seem particularly groundbreaking. Yet in reality, most antibiotics were identified over a half-century ago and new discoveries are quite rare. Teixobactin is actually "the first new antibiotic to be discovered in more than 25 years," according to the White House. After a "golden age" of discovery in the 1940s, 50s, and 60s, antibiotic development faltered.2,3 The drugs that were easiest to identify and cultivate (the "low-hanging fruit") had already been found, incentives in the scientific community steered research in other directions, and antibiotics were not seen as profitable by pharmaceutical companies.(a) MRSA bacteria Meanwhile, bacteria began to develop resistance to existing antibiotics. The dreaded MRSA (methicillin-resistant Staphylococcus aureus) arose in hospitals and healthcare facilities, while overuse of antibiotics in livestock farmin...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Ira Ekmekciu, Eliane von Klitzing, Christian Neumann, Petra Bacher, Alexander Scheffold, Stefan Bereswill, Markus M. Heimesaat
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
M ónica Carrera, Karola Böhme, José M. Gallardo, Jorge Barros-Velázquez, Benito Cañas, Pilar Calo-Mata
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Divakar Sharma, Yogesh K. Dhuriya, Nirmala Deo, Deepa Bisht
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: NCDs and their risk factors are emerging problems in Vietnam, which need both disease-specific and sensitive strategies in health and related sectors. PMID: 29222878 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
French baby milk maker Lactalis has ordered a global recall of millions of its products over fears of salmonella bacteria contamination
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
BACKGROUND: Altered cholesterol levels in body fluids and brain tissues have been shown to be associated with suicidal behaviour, violence and aggression. But the biological underpinnings of this association in the pathophysiology of suicide are not clear....
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Britain and China are among the countries affected by the recall of baby milk formula products.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Britain and China are among the countries affected by the recall of baby milk formula products.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
We present three individuals with SLOS and lesions in the basal ganglia or brainstem detected by MRI that were concerning for tumor formation. However, the individuals’ clinical and neurological course remained stable, and the lesions regressed after several years. These lesions have similarities to spongiotic changes observed in individuals with neurofibromatosis type 1 (NF1). Notably, impaired activity of small GTPases is present in both SLOS and NF1, perhaps giving mechanistic insight into the formation of these lesions.
Source: American Journal of Medical Genetics Part A - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
ConclusionsPdmF and PdmT were involved in 11‐O‐ and 7‐O‐methylations of the benzo[α]naphthacenequinone moiety of pradimicin, respectively. Methylation of the C‐7 hydroxyl group precedes methylation of the C‐11 hydroxyl group in pradimicin biosynthesis. Significance and Impact of the StudyThis is the first reported demonstration of the functions of PdmF and PdmT for regiospecific O‐methylation, which contributes to better understanding of the post‐PKS modifications in pradimicin biosynthesis as well as to rational engineering of the pradimicin biosynthetic machinery.
Source: Journal of Applied Microbiology - Category: Microbiology Authors: Tags: Original Article Source Type: research
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