Why We Need New Antibiotics More Than Ever

This article was produced in partnership with Northeastern University and was originally published on Footnote, a website that brings academic research and ideas to a broader audience. A year ago, a group of scientists led by Dr. Kim Lewis, Director of the Antimicrobial Discovery Center at Northeastern University, announced a major breakthrough. They had identified a new antibiotic, teixobactin, capable of destroying several kinds of bacteria, including antibiotic-resistant strains of tuberculosis and staph (i.e. MRSA).1 Antibiotics are so familiar to us that the discovery of a new one may not seem particularly groundbreaking. Yet in reality, most antibiotics were identified over a half-century ago and new discoveries are quite rare. Teixobactin is actually "the first new antibiotic to be discovered in more than 25 years," according to the White House. After a "golden age" of discovery in the 1940s, 50s, and 60s, antibiotic development faltered.2,3 The drugs that were easiest to identify and cultivate (the "low-hanging fruit") had already been found, incentives in the scientific community steered research in other directions, and antibiotics were not seen as profitable by pharmaceutical companies.(a) MRSA bacteria Meanwhile, bacteria began to develop resistance to existing antibiotics. The dreaded MRSA (methicillin-resistant Staphylococcus aureus) arose in hospitals and healthcare facilities, while overuse of antibiotics in livestock farmin...
Source: Science - The Huffington Post - Category: Science Source Type: news

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ConclusionThese results suggest that LLE may exert protective effects against NAFLD-related obesity and metabolic disease.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 July 2018Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): P. Rodríguez-Jiménez, I. Mir-Viladrich, P. Chicharro, G. Solano-López, F.J. López-Longo, C. Taxonera, P. Sánchez-Martínez, X. Martínez-Lacasa, M. García-Gasalla, J. Dorca, M. Arias-Guillén, J.M. García-García, E. DaudenAbstractPatients with chronic inflammatory diseases being treated with immunosuppressive drugs, and with tumor necrosis factor inhibitors in particular, have an increased risk of infection by Mycobacterium tuberculos...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Publication date: Available online 18 July 2018Source: Journal of Herbal MedicineAuthor(s): Eliana Harue Endo, Gustavo Meireles Costa, Regina Yasuko Makimori, Tania Ueda-Nakamura, Celso Vataru Nakamura, Benedito Prado Dias FilhoAbstractThe present study investigated the anti-staphylococcal effect of extracts of three species of plants (Rosmarinus officinalis, Punica granatum, Tetradenia riparia) against planktonic and biofilm cells of Staphylococcus aureus, including MRSA and MSSA. Minimal inhibitory and bactericidal concentrations (MIC and MBC) of hydroalcoholic extracts prepared with the leaves of R. officinalis and T. r...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
CONCLUSIONS: Colonization of S. aureus on the lesioned skin of AD patients contributes to not only an increase in the number of mast cells but also Th1 cell development mediated by mast cells in the dermis and subsequent induction of chronic inflammation, which is characterized by up-regulation of the Th1 cytokine, interferon (IFN)- g. Therefore, application of josamycin to the lesional skin of AD patients may provide relief from chronic inflammation mediated by mast cells. PMID: 30012242 [PubMed - in process]
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
DISCUSSION: Liver regeneration after PH is negatively influenced by CHOL diet. The increased uptake of cholesterol in the liver after PH associated with up-regulation of LDL receptor protein expression suggests preferential use of extrahepatic cholesterol by the liver. PMID: 30012246 [PubMed - in process]
Source: Acta Medica: Hradec Kralove - Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research
This study identified microbiota dysbiosis of gut microbiota in GAD patients, suggesting that targeting the microbiome may be a useful therapeutic and preventive target for GAD.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 17 July 2018Source: Clinica Chimica ActaAuthor(s): V. Higgins, S. Asgari, M.K. Chan, K. AdeliAbstractObjectivesIncreased prevalence of pediatric obesity and associated co-morbidities has heightened the concern for cardiovascular disease (CVD) risk later in life. Although the fasting lipid profile is traditionally used to assess CVD risk, the non-fasting lipid profile may simplify lipid testing and better predict CVD risk. Unfortunately, non-fasting lipid reference values are limited, particularly for children. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) h...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
ConclusionsThe 2016 guidelines appear to eliminate most of the flaws in the prior 2013 guidelines that replaced the ATP. They do not seem to rely on randomized control studies alone but the totality of all of the evidence. The new guidelines still fail to identify some persons with characteristics of metabolic syndrome that may be of increased risk for ASCVD although they address some of the problems in treating this group. The guidelines identify LDL cholesterol and nonHDL cholesterol target concentrations that are important for laboratory professionals since they should be defined on reports and are important for consultation.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
This article provides a detailed study design and protocol of HeCES2, an observational prospective cohort study with the objective to investigate the pathophysiology of carotid atherosclerosis. MATERIALS AND METHODS: Recruitment and carotid endarterectomies of the study patients with carotid atherosclerosis were performed from October 2012 to September 2015. After brain and carotid artery imaging, endarterectomised carotid plaques (CPs) and blood samples were collected from 500 patients for detailed biochemical and molecular analyses. Findings to date: We developed a morphological grading for macroscopic characteristic...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Adolescents who got enough sleep had a lower risk of metabolic problems.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Sleep Cholesterol Blood Pressure Teenagers and Adolescence Source Type: news
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