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Why We Need New Antibiotics More Than Ever

This article was produced in partnership with Northeastern University and was originally published on Footnote, a website that brings academic research and ideas to a broader audience. A year ago, a group of scientists led by Dr. Kim Lewis, Director of the Antimicrobial Discovery Center at Northeastern University, announced a major breakthrough. They had identified a new antibiotic, teixobactin, capable of destroying several kinds of bacteria, including antibiotic-resistant strains of tuberculosis and staph (i.e. MRSA).1 Antibiotics are so familiar to us that the discovery of a new one may not seem particularly groundbreaking. Yet in reality, most antibiotics were identified over a half-century ago and new discoveries are quite rare. Teixobactin is actually "the first new antibiotic to be discovered in more than 25 years," according to the White House. After a "golden age" of discovery in the 1940s, 50s, and 60s, antibiotic development faltered.2,3 The drugs that were easiest to identify and cultivate (the "low-hanging fruit") had already been found, incentives in the scientific community steered research in other directions, and antibiotics were not seen as profitable by pharmaceutical companies.(a) MRSA bacteria Meanwhile, bacteria began to develop resistance to existing antibiotics. The dreaded MRSA (methicillin-resistant Staphylococcus aureus) arose in hospitals and healthcare facilities, while overuse of antibiotics in livestock farmin...
Source: Science - The Huffington Post - Category: Science Source Type: news

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ConclusionsSpinach irrigated with RHW did not significantly affect the populations of fecal indicator bacteria when compared to CW‐irrigated spinach. Repeat irrigation with RCW is not recommended due to increased contamination of E. coli on spinach leaves. Significance and Impact of the StudyRHW may potentially be used as alternative irrigation water without deleteriously affecting the microbiological safety of the spinach.This article is protected by copyright. All rights reserved.
Source: Journal of Applied Microbiology - Category: Microbiology Authors: Tags: Original Article Source Type: research
CONCLUSION: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism. PMID: 29473534 [PubMed - as supplied by publisher]
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research
In conclusion, the developed anti-ROR1 PAb can be used as a tool for determining the prognostic value of ROR1 in histopathology of cancer tissues. PMID: 29474159 [PubMed - in process]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
In this study, we constructed an antibody-cytokine fusion protein (Ia1-TNFα) comprising the single-domain antibody Ia1, which targets epidermal growth factor receptor (EGFR) overexpressed in epithelial tumors and a tumor necrosis factor α (TNFα) domain, which has antitumor activity. Ia1-TNFα was produced in a soluble form by using an Escherichia coli expression system, and after affinity purification of the culture supernatant, an yield of ∼2 mg/L of cell culture was obtained. Gel filtration analysis showed that Ia1-TNFα existed predominantly as a trimer, which is consistent with th...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
This article is protected by copyright. All rights reserved. Recent findings have identified thousands of bacterial promoters in unexpected locations, such as inside genes. Here, we investigate the functions of intragenic promoters for the flagellar sigma factor FliA. Our data suggest that most of these promoters are not functional, but that one intragenic FliA promoter is broadly conserved, and constrains evolution of the overlapping protein‐coding gene. Our data suggest that intragenic regulatory sequences significantly impact bacterial genome evolution.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research
In this study we analysed expression of 42 genes from ABC transporter superfamily in both proliferating cells and differentiated neurons after treatment with silver nanoparticles. ABC transporter superfamily is especially known due to the involvement in multidrug resistance phenomenon, but also involvement in transport through blood-brain barrier. Our results indicate that in neurons silver nanoparticles mainly attenuate transporters responsible for maintaining asymmetry of cellular membrane and homeostasis of lipids and cholesterol. Our results revealed also that proliferating foetal brain cells are by far more susceptibl...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research
This study investigated the inactivation of Escherichia coli in a microbial electrolysis cell based bio-electro-Fenton system (renamed as microbial electrolytic-Fenton cell) with the aim to broad the application of microbial electrochemistry. Results showed that a 4-log reduction of Escherichia coli (107 to hundreds CFU/mL) was achieved with an external applied voltage of 0.2 V, 0.3 mM Fe2+ and cathodic pH of 3.0. However, non-notable inactivation was observed in the control experiments without external voltage or Fe2+ dose. The disinfection effect was enhanced when cathode air flow rate increased from 7 to 41 mL/min...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 May 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 165 Author(s): Hossam E. Emam, Osama M. Darwesh, Reda M. Abdelhameed Bio-active synthetic fabrics based on polyester (PET) and Nylon were manufactured by in-situ formation of Cu-BTC metal organic framework (MOF). In-growth of Cu-BTC within fabrics was accomplished in one pot simple process. The scanning microscope, X-ray diffraction and infrared spectra were all confirmed the formation of Cu-BTC within fabrics structure and reflected the role of fabrics' building unit in the Cu-BTC preparation. The estimated contents of materials onto fabri...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 20 May 2018 Source:Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 545 Author(s): Huijun Yin, Lihua Liu, Xin Wang, Tao Wang, Yuan Zhou, Bianfang Liu, Yuanyuan Shan, Lin Wang, Xin Lü Lignin nanoparticles (L-NPs) were firstly prepared from switchgrass lignin by using ultrasonic-assisted alkali method, after which L-NPs were assembled with gelatin to constitute L-NPs-gelatin complex as a novel flocculant. Both Gram-positive (Staphylococcus aureus, S.aureus) and Gram-negative (Escherichia coli, E.coli) strains were used to investigate the flocculation property of L-NPs and L-NPs...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 24 February 2018 Source:Veterinary Microbiology Author(s): Helena Eriksson, Robert Söderlund, Linda Ernholm, Lennart Melin, Désirée S. Jansson Salmonella Gallinarum biovar Pullorum (S. Pullorum) is a poultry pathogen associated with significant economic losses and animal suffering. Strict eradication programmes have eliminated S. Pullorum from the commercial poultry sector in most regions, but occasional outbreaks still occur in the non-commercial population. In 2012, pullorum disease was diagnosed in a non-commercial flock in Sweden. Epidemiological, post-mortem and b...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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