Tagenols A and B: New lipoxygenase inhibitor flavonols from Tagetes minuta
Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Gamal A. Mohamed Phytochemical investigation of the methanolic extract of Tagetes minuta L. (Asteraceae) aerial parts afforded two new flavonol derivatives: tagenol A (quercetagetin-8-hydroxy-3,6,4′-trimethy ether) (1) and tagenol B (quercetagetin-8-hydroxy-3-methoxy-6-O-β-d-glucopyranoside) (4), together with three known flavonoids: quercetin-3,6-dimethyl ether (2), quercetin-3-methyl ether (3), and axillarin-7-O-β-d-glucopyranoside (5). Their structures were identified by UV, IR, 1D (1H and 13C), 2D (1H–1H COSY, HSQC, and HMBC) NMR, and HRESIMS spectral data as well as comparison with literature data. The isolated compounds were evaluated for their lipoxygenase inhibitory and antioxidant activities. Compounds 1–5 displayed moderate lipoxygenase inhibitory activities with IC50 values of 12.2, 9.4, 7.1, 5.8, and 4.2μM, respectively compared to indomethacin (IC50 0.9μM). Moreover, they displayed promising antioxidant activities with IC50 values of 14.9, 14.3, 13.5, 12.7, and 11.2μM, respectively using DPPH assay compared to propyl gallate (IC50 7.38μM). Graphical abstract
Publication date: Available online 16 November 2019Source: Journal of Health EconomicsAuthor(s): Dimitris Christelis, Dimitris Georgarakos, Anna Sanz-de-GaldeanoAbstractEconomic theory predicts that a reduction in background risk should induce financial risk-taking, particularly for individuals with low stock market participation costs. Hence, health insurance coverage could affect financial risk-taking by offsetting health-related background risk. We use a regression discontinuity design to examine whether Medicare eligibility at age 65 increases stockholding in the US and find that it does so for those with college educa...
In this study, serum IL6 was measured by ELISA, and the HSD11B1rs12086634(T/G) polymorphism was analyzed using a TaqMan allelic discrimination assay technique. There were statistically significant differences between the two studied groups concerning the serum IL-6 level and HSD11B1rs12086634(T/G) genotype distribution, with increased serum IL6 and increased frequencies of the GG and TG genotypes in patients with PCO. The GG genotype of HSD11B1 rs12086634(T/G) and its associated high level of serum IL-6 may represent genetic risk factors for PCOS.
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Tom Marcelissen, Kevin Rademakers
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Zhengzheng Xu, Guangzhe Ge, Bao Guan, Zhentao Lei, Xueyu Hao, Yuanyuan Zhou, Yue Shi, Huan Lu, Jilu Wang, Ding Peng, XiKang Wu, Huiying He, Bao Zhang, Xuesong Li, Liqun Zhou, Weimin Ci
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Pirus Ghadjar, Thomas Wiegel
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Elise De Bleser, Piet Ost
ConclusionThe CFQL-2 is a brief, reliable scale that effectively measures psychosocial aspects of QoL and is sensitive to changes in QoL in families of children with ASD or related neurodevelopmental disorders. Child externalizing behavior is strongly associated with reductions in multiple aspects of child and family psychosocial QoL.
ConclusionThis meta-analysis suggested a significant association between MTHFR gene polymorphism (C677T and A1298C) and ASD risk.
ConclusionGiven that obtaining negative margins is important in reducing the risk of recurrence, the method of surgical resection utilized is based on the amount of future functional residual hepatic parenchyma.
ConclusionsTattooing of axillary LNs is safe and easily performed. Tattooing was helpful in identifying the marked LN in the majority of cases. This technique helps to ensure that metastatic LNs are identified and removed at surgery after NAT.