The Zika Virus Lesson? A New Approach Is Needed to Combat Pandemics

The Zika virus attracted many headlines this winter, but a recent admission by the chief medical officer at a leading vaccine manufacturer -- that the world is ill-prepared to deal with pandemic outbreaks -- underscores a fundamental problem. To ensure safety and efficacy, the federal government's regulatory approval process for new vaccines may extend development timelines for years. So when The New York Times reports that "eighteen organizations are working on developing a vaccine for the Zika virus," it is likely that those companies will labor for a very long time. Vaccinations rightly require strict federal approval processes to ensure the safety and the efficacy of a new vaccination. But when pandemic viruses like Zika spread quickly and unexpectedly, the world realizes there is little that can practically and immediately be done other than to implement strict infection control measures up to and including quarantines. This has been true for prior pandemics such as the swine flu, avian flu, SARS and Ebola. That reality speaks to the need for a new approach to pandemic viruses, including influenza. The good news with Zika is that it is a fairly stable virus, unlike other frequently mutating viruses such as the influenza virus. During the Zika epidemic in Brazil, reported microcephaly cases rocketed to 2,700 in 2015 and at least 40 babies died. By comparison, there were only 147 reported microcephaly cases in Brazil altogether in 2014. In 60 to 80 pe...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Authors: Gallicchio R, Mastrangelo PA, Nardelli A, Mainenti PP, Colasurdo AP, Landriscina M, Guglielmi G, Storto G Abstract Radium-223 dichloride (223Ra) is the first, recently approved, α-particle-emitting radiopharmaceutical for the treatment of patients with bone metastases in castration-resistant prostate cancer (CRPC) and no evidence of visceral metastases. We explored MEDLINE, relevant congresses, and websites for data on 223Ra and prostate cancer therapies, focusing on therapeutic strategies and timing, bone metastases, and diagnostic assessment. 223Ra represents the only bone-targeting agent that has ...
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
Publication date: Available online 18 May 2019Source: Protein Expression and PurificationAuthor(s): Josselin Corzo-Gómez, Julio García Cordero, Alfredo E. Montes Gómez, Karen Bernal Siria, Karime Namorado-Tónix, Benito Gutiérrez Castañeda, Leticia Cedillo-BarrónAbstractThe envelope (E) protein from Dengue and Zika viruses comprises three functional and structural domains (DI, DII, and DIII). Domain III induces most of the neutralizing antibodies and, as such, is considered as having the highest antigenic potential for the evaluation of population-level surveillance and for d...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Authors: Bak H, Bang S, Yoo S, Kim S, Lee SY Abstract The quadratus lumborum block (QLB), which is based on an easy fascial plane technique that has been reported to be effective in pain control after abdominal surgery. Here we report a case involving an 83-year-old man (weight: 64 kg) who received continuous transmuscular QLB as part of a multimodal analgesia after hardware removal and total hip arthroplasty. The patient received continuous infusion of 0.2% ropivacaine at 8 mL/h through an indwelling catheter in addition to patient-controlled analgesia (PCA) with intravenous fentanyl and oral celecoxib. The area o...
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
[Extensive tinea corporis due to a terbinafine-resistant Trichophyton mentagrophytes isolate of the Indian genotype in a young infant from Bahrain in Germany]. Hautarzt. 2019 May 16;: Authors: Süß A, Uhrlaß S, Ludes A, Verma SB, Monod M, Krüger C, Nenoff P Abstract A 6 month-old-female infant from Bahrain visiting Germany with her family for a holiday was seen by us for extensive dermatophytosis of the back, buttocks, chest and groins. Topical treatment by terbinafine for over 2 months was not successful. Other family members including adults and chil...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Authors: Mayser P Abstract In a preschool a long-lasting outbreak of Trichophyton (T.) tonsurans tinea capitis was stopped by a concurrent screening of all persons at-risk (N = 264) with the hairbrush technique and a therapy based on clinical picture as well as on the quantitative results of the culture. In addition to the 5 symptomatic patients 10 asymptomatic carriers undetected until now were especially important as vectors. With the rising incidence of T. tonsurans and T. violaceum and the return of Microsporum (M.) audouinii in central Europe such outb...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Hey guys, Kinda getting slumped by pimp questions on appropriate pain management guidelines. Can someone please give me a brief idea regarding when to use what, or link me to one? Eg: Been suggesting toradol when attending thought opiods, been suggesting toradol when attending thought tylenol or vice versa, This is like the sixth time this has happened. Thanks in advance!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Emergency Medicine Source Type: forums
The star of ER and The Good Wife is back – as a doctor fighting to save humanity. She gives her bodyguard the slip to talk about our imperilled planet – and her love of Sussex A-roadsBefore I meet Julianna Margulies, I spend three days staring at her bodyguard. He ’s impossible to miss: one of those men whose every attempt to blend in flounders. Margulies and I are in Lille, judges at the Series Mania television festival, although our experiences differ a little. My cloak of anonymity allows me to roam the city unpestered. Margulies, however, has been a TV mainstay for 25 years, with roles in two juggerna...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Television Drama Ebola Infectious diseases Doctors Culture Society Epidemics Aid US television The Good Wife & radio Health Global development World news Africa Microbiology Science Medical research Source Type: news
Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Click arrow to play Download TWiV 548 (43 MB .mp3, 72 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology baculovirus Borna virus encaphalitis European Congress of Virology Lassa virus metagenomics nigeria outbreak response transplant recipient viral virus behavior modification viruses zombie caterpillar Source Type: blogs
We present the case of preseptal cellulitis in a 3-year-old child, caused by nonconsensual sexual contact with chlamydia trachomatis.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
ConclusionMinimally invasive removal of sacrocolpopexy mesh can be standardized using this step by step approach.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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