Therapeutic hypothermia in ST elevation myocardial infarction: a systematic review and meta-analysis of randomised control trials

Conclusions Although TH appears to be safe in patients with STEMI, meta-analysis of published RCTs indicates that benefit is limited to reduction of infarct size in patients with anterior wall involvement with no demonstrable effect on all-cause mortality, recurrent myocardial infarction or HF/PO.
Source: Heart - Category: Cardiology Authors: Tags: Bradyarrhythmias and heart block, Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology Coronary artery disease Source Type: research

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Conclusions Overall, a majority of patients recovered well postoperatively with minimal complications and low rate of reoperation. Our research provides a foundation to develop a risk-stratified approach to determine the need for an ICU admission or early transfer to floor care.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Microsurgery Source Type: research
ConclusionOur study suggests PRISM score performed as well as modified SHFM for one-year mortality prediction. Moreover, the addition of modified SHFM to PRISM score increases discriminatory ability in predicting 1-year mortality in heart failure patients compared to either of the two models alone. Together, when combined in a CART model, they can be used to identify the population subset with the highest mortality risk and hence guide goals of care discussion.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Publication date: February 2020Source: IJC Heart &Vasculature, Volume 26Author(s): Xizhen Xu, Dao Wen WangAbstractBeta blockers are a recommended therapy in patients with heart failure with reduced ejection fraction(HFrEF). Beta blockers markedly and unequivocally reduce mortality in patients with heart failure with reduced ejection fraction. However, the beneficial effects of beta blockers in patients with heart failure with preserved ejection fraction(HFpEF) are not well established. In this review, we will assess the evidence basis of the recommendations for beta blockers and discuss emerging concerns about the use ...
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Authors: Michala L, Stefanaki K, Loutradis D Abstract Premature ovarian insufficiency (POI) is typically diagnosed when amenorrhea is combined with high gonadotrophins and hypoestrogenemia in a woman under 40 years of age, although, more rarely, POI can develop in adolescence and present with delayed puberty or amenorrhea, depending on the timing of follicular depletion or insult to the ovary. In a proportion of girls, the diagnosis may be made at an early stage of POI, presenting with abnormal uterine bleeding, when some follicular function is still retained. The natural history of POI in this group of patients is...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
In this study, we investigated the effects of these granules on myocardial fibrosis in a rat model of myocardial infarction in vivo. Methods: Male Wistar rats were randomly divided into four groups: the sham operation group, the acute myocardial infarction (AMI) group, the Luhong granule group, and the vancomycin group, with a sample size (n) of 10 rats in each group. The AMI model was established in all rats by ligation of the left anterior descending (LAD) coronary artery (the sham operation group did not undergo ligation). Luhong granules (0.5 ml·kg-1·d-1), vancomycin (0.075 g·ml-1...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusions: SAP bundle compliance was associated with a lower incidence of SSI's. In an ANN model, inclusion of the SAP bundle compliance reduced sensitivity, but increased specificity of the prediction model. Preoperative WBC count had the most influence on the model. PMID: 31827618 [PubMed]
Source: Patient Safety in Surgery - Category: Surgery Authors: Tags: Patient Saf Surg Source Type: research
Roever L, Tse G, Biondi-Zoccai G. Continuous positive airway pressure and adaptive servoventilation in heart failure patients with central sleep apnea with Cheyne Stokes respiration: are they useful in ameliorating cardiac systolic dysfunction?J Clin Sleep Med. 2019;15(12):1715–1716.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Study Objectives:Early evidence with transvenous phrenic nerve stimulation (PNS) demonstrates improved disease severity and quality of life (QOL) in patients with central sleep apnea (CSA). The goal of this analysis is to evaluate the complete prospective experience with PNS in order to better characterize its efficacy and safety, including in patients with concomitant heart failure (HF).Methods:Using pooled individual data from the pilot (n = 57) and pivotal (n = 151) studies of the remedē System in patients with predominant moderate to severe CSA, we evaluated 12-month safety and 6- and 12-month effectiveness based on p...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:CPAP and ASV are effective in improving LVEF in patients with heart failure and CSA/CSR to a clinically relevant amount, whereas nocturnal O2 is not. There is no difference between CPAP and ASV in the comparative beneficial effect on cardiac function.Citation:Schwarz EI, Scherff F, Haile SR, Steier J, Kohler M. Effect of treatment of central sleep apnea/Cheyne-Stokes respiration on left ventricular ejection fraction in heart failure: a network meta-analysis.J Clin Sleep Med. 2019;15(12):1817–1825.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
This study proposed an approach based on deep learning that combined convolutional neural networks (CNNs) and long short-term memory networks (LSTM) to automatically identify six types of ECG signals: normal (N) sinus rhythm segments, atrial fibrillation (AFIB), ventricular bigeminy (B), pacing rhythm (P), atrial flutter (AFL), and sinus bradycardia (SBR). The proposed network applied a multi-input structure to process 10 s ECG signal segments and corresponding RR intervals from the MIT-BIH arrhythmia database. With a five-fold cross-validation strategy, this network achieved 99.32 % accuracy. Then, the diversity of the ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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