Hacking Gut Bacteria Could Be The Future Of Medicine

The human gut microbiome -- which includes the community of trillions of bacteria living within our intestines -- has been called one of the next big frontiers in medicine.  In recent years, a growing body of research has shown that the bacteria in our gut exert a powerful influence on our immune and endocrine systems, brain health, mood and cognitive function, and other key biological processes. We know that the balance of good and bad bacteria in the gut can keep us healthy -- or can contribute to disease. Now, the next step for this exciting medical frontier is learning how to leverage the power of the microbiome to treat disease.  In new research, biologists and medical engineers at the Massachusetts Institute of Technology are doing just that by reprogramming gut bacteria to act as "living therapeutics" that can correct the metabolic dysfunctions underlying certain ailments. "It's become really clear that the bacteria living in us and on us affect our bodies in a variety of different ways -- in ways that we never imagined," Dr. Timothy Lu, a biological engineer at MIT, told The Huffington Post. "The old idea that people are just people and that everything that happens in our bodies is dictated by human cells and DNA is probably not the complete picture."  At the MIT offshoot biopharmaceutical lab Synlogic, which Lu co-founded, scientists are working to create a new class of medications called &quo...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
OBJECTIVE: Primary Sj ögren ’ s syndrome (pSjS) is a chronic autoimmune disease that causes dry eye and mouth. No laboratory parameters to monitor the activation of this disease have been identified. Therefore, any possible relationships between salivary and blood myxovirus resistance 1 (MX1) and pSjS must be prospectively studied. METHODS: Thirty female patients with pSjS, 30 women with rheumatoid arthritis (RA) without secondary Sj ögren ’ s syndrome (SjS) and 28 healthy control women were enrolled in this investigation. Analyses of MX1 by the enzyme-linked immunosorbent assay (ELISA) method, SS-A (...
Source: Clinics - Category: General Medicine Source Type: research
Publication date: Available online 31 May 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Fumi Varyani, Sunil SamuelAbstractCrohn's disease is a form of chronic inflammatory bowel disease that can lead to structural bowel damage due to transmural inflammation. Ileo-colonosocopy is currently essential for initial diagnosis. Reassessment of disease burden is frequently needed during episodes of active disease and when evaluating treatment efficacy. This review compares the role of Magnetic Resonance Enterography (MRE) and ileocolonoscopy in Crohn's disease management and whether cross-sectional im...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
No abstract available
Source: Pancreas - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
ConclusionsPatients with moderate –severe CD with prior primary-nonresponse to SC, fixed-dose TNFs, subsequently treated with IV, weight-based TNF have high rates of clinical and endoscopic response and remission. Therefore, despite primary-nonresponse to SC TNFs, patients may benefit from IV TNF therapy and may not require a chan ge to a different class of biologic therapy.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Sinem Diken Gür, Monireh Bakhshpour, Adil DenizliAbstractThe aim of the present study was developing a surface plasmon resonance (SPR) nanosensor to detect Escherichia coli (E. coli) for the diagnosis of urinary tract infections by using surface imprinted Au nanoparticles (AuNPs) as a recognition element. In order to realize imprinting, Cu(II) ions were used to provide interaction between E. coli cell wall and amine functionalized AuNPs forming cavities on the surface of nanosensor. E. coli surface imprinted AuNPs nanosen...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Anyone who remembers the days before finger stick blood glucose meters became available to people with diabetes will recall how awful life was for diabetics. All they had was urine dipsticks which were sloppy, yielded only crude non-quantitative feedback on blood sugars, and gave you a gauge of what blood sugars were in the recent past, not the present. It meant that dosing insulin or diabetes drugs was grotesquely imprecise and accounted for many episodes of hypoglycemic coma and acceleration of diabetic complications. It was not uncommon in those days, for instance, for a type 1 diabetic to be blind and experience kidney...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO bowel flora Inflammation probiotic undoctored wheat belly Source Type: blogs
Publication date: 18 June 2019Source: Cell Reports, Volume 27, Issue 12Author(s): Bi-Huei Yang, Ke Wang, Shuo Wan, Yan Liang, Xiaomei Yuan, Yi Dong, Sunglim Cho, Wanqing Xu, Kristen Jepsen, Gen-Sheng Feng, Li-Fan Lu, Hai-Hui Xue, Wenxian FuSummaryCD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg’s differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient expression of TCF1 and LEF1 distinguishes Tregs into three di...
Source: Cell Reports - Category: Cytology Source Type: research
CONCLUSION: Metronidazole, tinidazole, and nitazoxanide are the drugs of choice. Resistance to common antigiardial drugs has increased in recent years. As such, the search for new molecular targets for antigiardial drugs is urgently needed. In general, treatment of asymptomatic carriers is not recommended. Purification of water supply is an important preventive measure. PMID: 31210116 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
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