Cardiac Reserve

Thursday, March 6, 2014    Pomalyst Study Cycle 78: My Doctor L and the crew of three CNP's were all unavailable for this visit to Mayo, so I saw Dr MG instead. In terms of the Mayo Clinic hierarchy, that's an upgrade. We had met before, but he had not seen me as a patient. We quickly agreed that the myeloms was still stable, and he in fact commented that the Pomalyst trial has been a home run for me. Indeed! Six years now, and still counting - I am so fortunate. IgG was up just slightly, but Lambda light chains are down a little, and maybe both changes are within measurement error anyway. No change. I am starting Cycle 79, continuing to hope and pray. We discussed last month's influenza A and accompanying pneumonia at some length. He gave me a rather thorough chest exam, listening carefully to breath and heart sounds, and pronounced the breathing clear and the heartbeats strong and steady. Three different doctors have treated or examined me now regarding that pneumonia, and all three have volunteered, without my asking, that my fitness may have played a role in my recovery. Today Dr. MG used the term "cardiopulmonary reserve," (I think that was the term), and remarked that a person without that reserve might might have recovered more slowly, if at all. Of course there is no proof that fitness played a part, only opinions. Nevertheless I'm a true believer, and I think that my immune system may be stronger because of that fitness. To achieve that, we: ...
Source: Myeloma Hope - Category: Cancer Source Type: blogs

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In conclusion, data revealed no correlation between ex vivo and in vivo studies explained by the collapse of the follicles in ex vivo skin permeation study, leaving only the lipoidal pathway for NE to pass through, thus only NE components, neither nanosizing nor other reported mechanisms, are the main influencing factors. In vivo experiments suggested that o/w NE changed ATOR pathway to follicular delivery leading to accumulation of NE in follicles and consequently a prolonged plasma profile.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
FDA-AACR Workshop to Examine Under-representation of African Americans in Multiple Myeloma Clinical Trials
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Publication date: Available online 22 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Arian Lasocki, Emma-Jane Furphy, David A. Westerman, Simon HarrisonAbstractVisual disturbance is a common complaint in patients with multiple myeloma, both at diagnosis and later in their course, and has a broad differential. Here, we report a novel cause of visual disturbance, namely retinal ischemia due to extramedullary plasmacytomas of the orbit. A 69 year-old male patient with known multiple myeloma presented with reduced vision in his left eye. The patient had been initially diagnosed with IgG myeloma 9 mont...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Pregnant women need to receive vaccines during pregnancy to keep themselves and their infants safe. Barriers to receiving vaccines, such as lack of insurance coverage, need to be removed so mothers and infants can be protected.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Influenza Vaccination MMWR Morbidity & Mortality Weekly Report Pregnancy Source Type: news
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Source: Cranio - Journal of Craniomandibular and Sleep Practice - Category: Sleep Medicine Authors: Source Type: research
Discussion and conclusion: Our results demonstrated that sildenafil decreased pathological changes in alveoli, bronchioles, interstitial tissue, and arterioles of rats with COPD and PH. PMID: 31967915 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Publication date: Available online 22 January 2020Source: Life SciencesAuthor(s): Ya-Shuo Feng, Si-Dong Yang, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng ZhangAbstractParkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 January 2020Source: Journal of Structural BiologyAuthor(s): Yuval Kadan, Lior Aram, Eyal Shimoni, Smadar Levin-Zaidman, Shilo Rosenwasser, Assaf GalAbstractThe formation of coccoliths, intricate calcium carbonate scales that cover the cells of unicellular marine microalgae, is a highly regulated biological process. For decades, scientists have tried to elucidate the cellular, chemical, and structural mechanisms that control the precise mineralogy and shape of the inorganic crystals. Transmission electron microscopy was pivotal in characterizing some of the organelles that orchestrate t...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Publication date: Available online 22 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Arghadip Samaddar, Anuradha Sharma, Twishi ShrimaliAbstractAcrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. He had a past history of pulmonary tuberculosis and was a known case of chronic obstructive pulmonary disease for past five years. He was diagnosed with mixed connective tissue disease and had been receivin...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
BACKGROUND: Sleep is a reliable correlate of suicidal thoughts and behaviors (STBs), yet few studies have directly examined negative affect in the context of this association. The present study combined daily experience methods with a laboratory paradigm t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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