Inhibition of the Nuclear Receptor RORγ and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia.

CONCLUSIONS: Our findings indicate that an RORγ/IL-17A axis influences VEGF production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORγ and IL-17A may have potential for the improved treatment of neovascular retinopathies. PMID: 27055905 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27055905?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 6, 2016 Category: Cardiology Authors: Talia DM, Deliyanti D, Agrotis A, Wilkinson-Berka JL Tags: Arterioscler Thromb Vasc Biol Source Type: research