α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy

In conclusion, this study defines the α-synuclein-induced myelination deficit as a novel and crucial pathomechanism in MSA. Importantly, the reversible nature of this oligodendrocytic dysfunction opens a novel avenue for an intervention in MSA.

http://link.springer.com/10.1007/s00401-016-1572-y

Source: Acta Neuropathologica - April 7, 2016 Category: Neurology Source Type: research