A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma

Conclusions Pevonedistat was generally well tolerated at the MTD. Anticipated pharmacodynamic effects of NAE inhibition were observed with single-agent pevonedistat in peripheral blood and tumor tissue.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens. Drug Dev Ind Pharm. 2019 Aug 16;:1-21 Authors: Maravić A, Rončević T, Krce L, Ilić N, Galić B, Čikeš Čulić V, Carev I Abstract Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistan...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Authors: Abdel-Rahman O Abstract Objective: To assess the prognostic impact of socioeconomic status (SES) on the outcome of cases with cutaneous melanoma. Methods: Novel SEER socioeconomic database has been accessed and patients with malignant melanoma of the skin (2000-2015) were reviewed. SES was evaluated through a specialized multi-dimension index and patients were classified into three groups (group 1/2/3) where group 1 has the lowest SES and group 3 has the highest SES. Kaplan-Meier survival estimates were used to evaluate the impact of SES on overall survival and multivariable Cox regression analysis was use...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
We appreciate the interest that Roncati and Piscioli showed in our recent publication, in which we evaluated the risk of sentinel lymph node (SLN) metastases in nonulcerated, T1b melanoma by the new 8th edition American Joint Committee on Cancer (AJCC) staging criteria.1 The authors propose a model of melanoma progression based on the transition from a radial growth phase to a vertical growth phase (VGP) that can predict biologic aggressiveness and propensity to metastasize.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system for melanoma no longer considers the mitotic count in the a or b T1 categorization, but it adopts a sub-stratification based on Breslow depth: T1a ≤ 0.8 mm without ulceration and T1b ≤ 0.8 mm with ulceration or 0.8 to 1 mm with or without ulceration. Skin melanoma can be subdivided by Breslow depth into thin melanoma (≤1 mm) or thick melanoma (>1  mm). According to the AJCC 8th Edition, a and b specifications are assigned based on ulceration and depth, which replace the mitotic count for square millimeter.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
ConclusionsResidual disease may be inconspicuous or absent on cytology, colposcopy and/or histology. Management taking account of risk of recurrence (age, CIN3 depth, incomplete initial excision) could avoid some post-treatment cancers.
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
ConclusionOur initial results show that the videoscopic inguinal lymphadenectomy is an attractive alternative to the conventional open technique. The number of complications is comparable with the complication rate reported for the conventional open procedure, but they are less severe and there is no need for a surgical re-intervention.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 17 July 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Katie S. Traylor, Nicholas Koontz, Kristine MosierThe incidence of head and neck cancer continues to rise annually, most commonly squamous cell carcinoma (SCCa). Advances in imaging techniques have improved diagnostic accuracy with important ramifications for initial staging and post-treatment surveillance. FDG-PET/CT and, more recently, FDG-PET/MRI have revolutionized the staging and surveillance of head and neck SCCa. We detail the diagnostic role of FDG-PET/CT and FDG-PET/MRI of SCCa at the different head and neck subsite...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Conclusions53BP1-NF accumulation increases during cancer progression from LG-IN to HG-IN to CIS to SCC. Detection of 53BP1-NF by immunofluorescence, especially large foci, is a feasible method of estimating DNA instability and the malignant potential of esophageal intraepithelial neoplasia.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In conclusion, our study firstly revealed the LINC00963/miR-1193/SOX4 axis in CSCC, indicating miR-1193 as a promising biological target in CSCC progression.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Authors: Seeger J, Romero M, Schuh C, Virmani R, Wöhrle J Abstract BACKGROUND: Use of the dual-filter cerebral embolic protection (CEP) device has been linked to a lower stroke rate in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR). Captured debris is found in almost every filter. The impact of repositioning on number and area of captured debris has not been studied. METHODS: Consecutive patients (n = 200) undergoing transfemoral TAVR with double-filter CEP device were included. A total of 400 filters were analyzed. Histopathologic assessment and histomorphometric analyses o...
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
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