The presence of the anti-inflammatory protein MAM, from Faecalibacterium prausnitzii, in the intestinal ecosystem

We recently reported in your journal the discovery of an anti-inflammatory protein produced by Faecalibacterium prausnitzii, a commensal bacterium involved in Crohn's disease (CD) dysbiosis.1 We wish to highlight and complete these recent data. The involvement of the intestinal microbiota in the pathogenesis of CD is well recognised. It has been shown that dysbiosis (an imbalance in the composition of the intestinal microbiota) could participate in chronic and inappropriate activation of the intestinal immune system and lead to inflammation. Dysbiosis is characterised by a deficiency of certain bacteria, such as Faecalibacterium prausnitzii, which belongs to the Clostridium leptum group.2 A consortium led by Pr Philippe Seksik has shown that loss of F. prausnitzii from the intestinal microbiota is associated with development of IBD, suggesting an anti-inflammatory role for this bacterium. This assessment was subsequently verified in cellular and animal models.3 Our recent...
Source: Gut - Category: Gastroenterology Authors: Tags: PostScript Source Type: research