Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1

Conclusions
Decreased colonic miR-199a/b correlates with visceral pain in patients with IBS-D. Similarly, reduced miR-199a expression in rat DRG and colon tissue is associated with heightened visceral hypersensitivity. In vivo upregulation of miR-199a decreases visceral pain via inhibition of TRPV1 signalling. Thus, miR-199 precursors may be promising therapeutic candidates for the treatment in patients with visceral pain.

Source: Gut - April 7, 2016 Category: Gastroenterology Authors: Zhou, Q., Yang, L., Larson, S., Basra, S., Merwat, S., Tan, A., Croce, C., Verne, G. N. Tags: Endoscopy, Irritable bowel syndrome, Open access, Colon cancer Neurogastroenterology Source Type: research