Proton pump inhibitors affect the gut microbiome
Conclusions
The differences between PPI users and non-users observed in this study are consistently associated with changes towards a less healthy gut microbiome. These differences are in line with known changes that predispose to C. difficile infections and can potentially explain the increased risk of enteric infections in PPI users. On a population level, the effects of PPI are more prominent than the effects of antibiotics or other commonly used drugs.
Source: Gut - Category: Gastroenterology Authors: Imhann, F., Bonder, M. J., Vich Vila, A., Fu, J., Mujagic, Z., Vork, L., Tigchelaar, E. F., Jankipersadsing, S. A., Cenit, M. C., Harmsen, H. J. M., Dijkstra, G., Franke, L., Xavier, R. J., Jonkers, D., Wijmenga, C., Weersma, R. K., Zhernakova, A. Tags: Clostridium difficile, Open access Gut microbiota Source Type: research
More News: Clostridium Difficile | Enterococcus | Gastroenteritis | Gastroenterology | Genetics | Proton Pump Inhibitors PPIs | Study