Reply

We thank Dr. Madias 1 for his interest in and comments concerning our report, which describes the incidence, characteristics, risk factors, and outcomes of Takotsubo cardiomyopathy with and without ventricular arrhythmia 2. In Takotsubo cardiomyopathy, albeit several physiological hypotheses have been suggested, a hyperadrenergic mechanism, excessive sympathetic responsiveness associated with a reduced parasympathetic modulation of heart rate is more commonly evocated 3,4. Several authors have suggested that diabetes mellitus (DM), responsible of autonomic nervous system neuropathy and adrenal cathecholamine hyposecretion, could have a protective effect on Takotsubo cardiomyopathy 5, 6.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research