The ex vivo L-CBMN assay detects significant human exposure to butadiene

Publication date: Available online 6 April 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Claudia Bolognesi, Micheline Kirsch-Volders 1,3-butadiene (BD), an important industrial chemical used in the production of synthetic rubber and resins and a ubiquitous environmental pollutant, was classified as a human carcinogen by IARC. BD requires metabolic activation to different epoxides that are known to bind to DNA, inducing also DNA-DNA and DNA-protein crosslinks. The DNA damage leading to mutations has been identified as the mode of action of BD. Experimental studies in rodents revealed widely different BD carcinogenic/mutagenic potency in rat and mice, associated to differences in BD metabolism. The available biomonitoring studies in workers occupationally exposed to BD, considering different genetic endpoints, don’t allow to reach a conclusion on the BD carcinogenic/mutagenic risk in humans. The present systematic review retrieves and analyzes the published studies on the application of the cytokinesis-block micronucleus assay in peripheral lymphocytes (L-CBMN) of BD exposed subjects. Ten articles were retrieved related to seven studies on BD exposure and one study on exposure to a mixture of compounds in a styrene-butadiene tire manufacturing plant. Four studies carried out in Europe related to heterogeneous groups of workers exposed in BD monomer or polymer manufacturing and processing industries, reporting mean individual exposure levels bel...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research