Boy with has rare disease LCH causing 'chicken pox' lumps all over his body

Oscar Langham, 10 months old, of Leek, Staffordshire, suffers from Langerhans' cell histiocytosis, a rare disease of the immune cells which causes an angry red rash.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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We report two cases of ECD-LCH “overlap syndrome” occurring in the lung. In both cases, the diagnoses were supported by typical immunohistochemical patterns, and in both cases, the BRAF V600E mutation was identified by next-generation sequencing and confirmed by droplet digital polymerase chain reaction. In neither case was either diagnosis suspected. The recognition of overlap histiocytoses is important. Although LCH and ECD may differ in treatment and prognosis, in some cases, such as the two patients reported here, they may have the same activating mutations and may be able to be treated with the same targeted therapy.
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reviews Source Type: research
Langerhans cell histiocytosis (LCH) is a rare disease that mainly affects children, but this disease is significantly rarer in patients who are older than 15  years. In this disease, any organ can be involved. ...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Case report Source Type: research
Pneumothorax may recur during pulmonary Langerhans cell histiocytosis (PLCH) patients ’ follow-up and its management is not standardised. The factors associated with pneumothorax recurrence are unknown.
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
We report a rare case of mandibular condyle unifocal HL mimicking a temporomandibular joint disorder. CASE REPORT: A 44-year-old patient presented with a left temporomandibular disorder with painful left preauricular swelling. The imaging assessment found a bone lesion of the left mandibular condyle. A curettage with biopsy was used to diagnose HL. Six months later, the patient had no more pain. DISCUSSION: The craniofacial clinical expressions of HL mainly concern the bones, which can cause: pain, swelling, fracture, compression of noble organs. The other sites are: oral cavity, skin, lymph nodes, or eyes. Isolate...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
In this report, we present a case of an adult female who was found to have a cecal polyp on a routine screening colonoscopy. The histopathological examination and immunohistochemical studies confirmed the diagnosis of LCH. We also review the literature of adults LCH manifested in GI mostly colonic polyps.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe particularity of this observation is the bilaterality of the lesion on both forearms and it has not previously been reported. Langerhans cell histiocytosis should be included in the differential diagnosis of osteomyelitis and Ewing ’s sarcoma.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
ConclusionsA very unusual hip joint lesion of xanthoma disseminatum was replaced with a total artificial joint replacement, and the course over 4  years was good. Our patient’s course will continue to be followed carefully.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: 2019Source: European Journal of Radiology Open, Volume 6Author(s): P. Lomoro, I. Simonetti, G. Vinci, V. Fichera, L. Tarotto, P. Trovato, M.S. Prevedoni GoroneAbstractLangerhans cell histiocytosis (LCH) is a rare disease of the myeloid precursor cells, it predominantly occurs in the skull and long bones as unifocal bone lesions. Aneurysmal bone cysts (ABC) are benign, expansive and lytic bone. Reports of secondary ABC occurring in LCH are rare, having only been reported twice in the skull. Here, we report the first case of LCH masquerading as ABC in a 14-month-old female child who presented with a rapidly...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
Langerhans cell histiocytosis (LCH) is characterized by the congregation of proliferating langerhans cells (LC). Langerhans cells are a part of dendritic cell system of primary immune response that is responsible for presenting antigen to lymphocytes. Being a rare disease, the total incidence of LCH is reported to be 1 in 2 million people. LCH mainly affects children and young adults, with a slight male predilection. LCH is clinically divided into three groups namely Letter-Siwe disease (multiple multi organ affecting LCH at very young age), Hand-Schuler-Christian disease (LCH of bone involvement exophthalmos and diabetes ...
Source: Journal of Dentistry, Shiraz University of Medical Sciences - Category: Dentistry Source Type: research
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