Delayed Neuromyelitis Optica Masqueraded as Post Viral Encephalomyelitis (P6.159)
CONCLUSIONS Viral infection can be the triggering mechanism for the development of NMO disease.Disclosure: Dr. Rothstein has nothing to disclose. Dr. Majidi has nothing to disclose.
We describe a middle-aged woman with chronic GVHD after allo-HCT who presented with a rapidly progressive cerebellar syndrome. Thorough investigation revealed only cerebellar atrophy on brain imaging and positive anti-GAD65 antibodies in serum and cerebrospinal fluid suggesting the diagnosis of anti-GAD antibody-associated cerebellar ataxia. Despite prompt treatment with high-dose corticosteroids, intravenous immunoglobulins, and rituximab, the patient ’s condition rapidly deteriorated, and she died 4 months later. This case suggests that anti-GAD antibody-associated cerebellar ataxia may be a rare manifestation of c...
Authors: Navarini L, Bisogno T, Margiotta DPE, Piccoli A, Angeletti S, Laudisio A, Ciccozzi M, Afeltra A, Maccarrone M Abstract Objective: Systemic lupus erythematosus (SLE) is an autoimmune systemic disease and its pathogenesis has not yet been completely clarified. Patients with SLE show a deranged lipid metabolism, which can contribute to the immunopathogenesis of the disease and to the accelerated atherosclerosis. Resolvin D1 (RvD1), a product of the metabolism of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), acts as a specialized proresolving mediator which can contribute in restoring the ...
Yonghong Yang, Cuiling Wang, Panpan Cheng, Xiaobei Zhang, Xuehui Li, Yuan Hu, Feihong Xu, Feng Hong, Guanjun Dong, Huabao Xiong
CONCLUSION: This well-documented case highlighted FCE as the preferential location for CNV development in PIC with multimodal imaging emphasizing a chorioretinal entity. SUMMARY: This case report demonstrated the clinical course of focal choroidal excavation in a patient initially diagnosed with punctate inner choroidopathy complicated by choroidal neovascularization and its treatment response, well documented by multimodal imaging including optical coherence tomography angiography. PMID: 30422049 [PubMed - as supplied by publisher]
Authors: Rego SL, Harvey S, Simpson SR, Hemphill WO, McIver ZA, Grayson JM, Perrino FW Abstract Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease. TREX1 degrades single- and double-stranded DNA (dsDNA), and the link between failed DNA degradation by nucleases, including nucleos...
ConclusionThis study has shown that a fluorescence imaging system applied with indocyanine green is a safe, easy and effective method to protect the parathyroid and predict postoperative parathyroidism.Trial RegistrationChinese Clinical Trial Registry no. ChiCTR1800016864.
A new report from the CDC shows that tickborne diseases like Lyme and Rocky Mountain spotted fever continue to rise
The EARLY trial also suggests that if there is a delay in sending a patient with non-ST- segment-elevation ACS to the cath lab, the patient should receive aggressive guideline-based medical therapy.Medscape Medical News
CONCLUSION: NLR, PLR and eosinophil count values could be predictive for etiological factors (traumatic SAH or spontaneous SAH) of patients who were admitted unconscious to the emergency room with SAH detected on radiological imaging. PMID: 30417744 [PubMed - as supplied by publisher]
(MedPage Today) -- Remission at months 3 and 6 protected against death and end-stage renal failure