Biomarker Confirmed Alzheimers Disease Presenting as Amnestic, Aphasic, and Visual Variants: Hippocampal Volume Comparison (P5.181)

CONCLUSIONS: Findings suggest that despite being similar amyloid pathology, brain topography, e.g., hippocampal atrophy, corresponds to the clinical presentation. Future work on cortical thickness differences among these groups may provide additional information regarding differential brain region compromise. Study supported by: National Institute on Deafness and Other Communicable Disorders R01 DC010367; Mayo Alzheimer’s Disease Research Center NIA P50 AG 16574Disclosure: Dr. Butts has nothing to disclose. Dr. Machulda has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Drubach has received research support from Allon Therapeutics. Dr. Przybelski has nothing to disclose. Dr. Ronald Petersen received personal compensation from Pfizer, Inc., Janssen Alzheimer's Immunotherapy. Merck, inc. Roche, Inc. Genentech, Inc. Biogen, Inc. Eli Lilly and Co. as a consultant or speaker. Dr. Jack has received personal compensation for activities with Janssen Research & Development, LLC by providing consulting services. Dr. Jack has received research support from the National Institutes of Health (R01-AG011378, RO1-AG041851, RO1-AG037551. Dr. Lowe has received personal compensation for activities with Bayer Pharmaceuticals as a consultant. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.

Source: Neurology - April 3, 2016 Category: Neurology Authors: Butts, A., Machulda, M., Duffy, J., Strand, E., Drubach, D., Przybelski, S., Petersen, R., Jack, C., Lowe, V., Josephs, K., Whitwell, J. Tags: Aging and Dementia: Atypical Dementia Source Type: research