The Monro-Kellie Doctrine in Action: Posterior Reversible Leukoencephalopathy Syndrome (PRES) Due to Intracranial Hypotension from Lumbo-Peritoneal Shunt Placement (P3.207)

CONCLUSIONS: IH appears to be a distinct, under-reported cause of PRES. It occurs in susceptible patients, on average 2-5 days after the IH trigger, and seems clinically and radiologically similar to the more common hypertensive cases, both in terms of initial presentation and prognosis. In accord with the Monro-Kellie doctrine stating that the sum of brain, blood and CSF volume is constant, venous sinus engorgement associated with IH could increase the hydrostatic pressure in the brain arterioles and capillaries, resulting in interstitial extravasation and brain edema of PRES. Increased vigilance is required to allow for prompt recognition and management. Study Supported by: N/ADisclosure: Dr. Nuccio has nothing to disclose. Dr. Amadio has nothing to disclose. Dr. Fountain has nothing to disclose. Dr. Karakis has nothing to disclose.

Source: Neurology - April 3, 2016 Category: Neurology Authors: Nuccio, A., Amadio, J., Fountain, A., Karakis, I. Tags: Neurocritical Care: Clinical Science Source Type: research