XANTUS: a real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation

Aims Although non-vitamin K antagonist oral anticoagulants are recommended for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) based on clinical trial results, there is a need for safety and efficacy data from unselected patients in everyday clinical practice. XANTUS investigated the safety and efficacy of the Factor Xa inhibitor rivaroxaban in routine clinical use in the NVAF setting. Methods and results Consecutive consenting patients with NVAF newly started on rivaroxaban were eligible and were followed up at ~3-month intervals for 1 year, or for at least 30 days after permanent discontinuation. All adverse events (AEs) were recorded as AEs or serious AEs; major outcomes (including major bleeding, symptomatic thromboembolic events [stroke, systemic embolism, transient ischaemic attack, and myocardial infarction], and all-cause death) were centrally adjudicated. There were 6784 patients treated with rivaroxaban at 311 centres in Europe, Israel, and Canada. Mean patient age was 71.5 years (range 19–99), 41% were female, and 9.4% had documented severe or moderate renal impairment (creatinine clearance
Source: European Heart Journal - Category: Cardiology Authors: Tags: Atrial fibrillation Source Type: research

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Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
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Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
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Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
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Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
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Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
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Source: Vascular - Category: Surgery Authors: Tags: Vascular Source Type: research
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Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
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