Natural biology and management of nonmuscle invasive bladder cancer

This article reviews the natural biology of noninvasive bladder cancer and its management strategies while summarizing the most recent advances in the field. Recent findings: Nonmuscle invasive bladder cancer (NMIBC) has a tendency to recur and progress. Risk stratification has helped triage patients but improved tools, including biomarkers, are still needed. Enhanced endoscopy with photodynamic imaging, narrow band imaging, optical coherence tomography and confocal laser endomicroscopy show promise for diagnosis, risk stratification and disease monitoring. Attempts at better treatment, especially in refractory high-risk cases, include the addition of intravesical hyperthermia, combination and sequential therapy with existing agents and the use of novel agents such as mycobacterial cell wall extract. New data are emerging regarding the potential role of active surveillance in low-risk patients. Summary: NMIBC represents a variety of disease states and continues to pose management challenges. As our understanding of tumor biology improves and technology advances, achieving better outcomes through individualized care may be possible.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: GENITOURINARY SYSTEM: Edited by Arif Hussain Source Type: research

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MC Abstract The performance of white light (WL) cystoscopy in the diagnostics of bladder cancer can be optimized by the use of modern imaging modalities, such as photodynamic diagnostics (PDD) and narrow band imaging (NBI). Real-time multispectral imaging (rMSI) enables simultaneous imaging of reflectance and fluorescence modalities in multiple spectral bands. We created a multiparametric cystoscopy image by digital overlapping of several modalities, e.g. WL, enhanced vascular contrast (EVC), raw fluorescence mode, protoporphyrin IX and autofluorescence (AF). The technical development and the subsequent...
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
This study was carried out in accordance with the recommendations of the Case Western Reserve University IACUC committee. The protocol was approved by the Case Western Reserve University IACUC committee. Author Contributions LRD and DW helped design research studies, analyze data and write the manuscript. ZL, RL, and ND conducted experiments, acquired and analyzed data, and assisted with manuscript preparation. LDM conducted experiments and analyzed data. FC assisted with research design. Funding This work was supported by the NIH P30CA043703, K1CA113838, and R01DK081395. Conflict of Interest Statement The authors de...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Author Siamak Daneshmand would like to note that this article published in Current Urology Reports inadvertently did not disclose financial information that could possibly be a conflict of interest.
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
Citing a lack of commercial progress, Mauna Kea Technologies is calling off an agreement with Cook Medical that was signed a little over three years ago involving Mauna Kea's Cellvizio platform. Paris, France-based Mauna Kea said the decision to terminate the development and distribution agreements with Cook was mutual. Cook has not officially commented on the news. Cellvizio is a multidisciplinary probe and needle-based confocal laser endoscopy platform. The device enables direct visualization of human tissues at the cellular scale and allows doctors to detect anomalies invisible with standard techniques, part...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Authors: Choi J, Lee MJ, Lee H, Kim Y, Han JH, Park SM Abstract Early removal of a percutaneous transhepatic biliary drainage (PTBD) tube commonly causes pneumoperitoneum. However, we encountered a patient who developed pneumoperitoneum even with an indwelling PTBD tube. An 84-year-old man was admitted with type III combined duodenal and biliary obstruction secondary to metastatic bladder cancer. A biliary stent was placed using a percutaneous approach, and a duodenal stent was placed endoscopically. A large amount of subphrenic free air was detected after the procedures. Laboratory tests indicated intestinal perfo...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
AbstractPurpose of ReviewEndoscopy coupled with targeted resections represents a cornerstone in the diagnosis, staging, and treatment of patients with bladder cancer. Direct visualization can be challenging and imprecise due to patient-, tumor-, and surgeon-specific factors. We will review contemporary endoscopic technologies and techniques used to improve our ability to safely identify and resect malignant lesions in patients with bladder cancer.Recent FindingsEnhanced endoscopic imaging technology may improve detection rates for bladder cancer throughout the upper and lower urinary tract, which may lead to improvements i...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
ConclusionAdditional to lower costs and no radiation exposure, 3D sonography appears comparable to the use of CT scans and MRI in providing virtual cystoscopy in investigating bladder cancer. Virtual sonographic cystoscopy may therefore be a useful alternative for screening and follow up of tumors, particularly if conventional cystoscopy cannot be performed. However, 3D sonography cannot replace pathological staging, and there is still a need to further improve this technology for enhanced assessment of mucosal abnormalities.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract OBJECTIVE: To report the sensitivity and specificity of neural precursor cell-expressed developmentally down-regulated protein 9 (NEDD9) protein high expression in predicting BCG response and its effect on recurrence or progression free survivals. PATIENTS AND METHODS: Between May 2014 and April 2017, a prospective cohort study was conducted on 105 patients with intermediate or high-risk nonmuscle invasive bladder cancer. Immunohistochemical staining with mouse monoclonal anti-NEDD9 antibody was done. Examination of the slides was done to detect NEDD9 cytoplasmic expression. Intravesical induction ba...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Conclusion Additional to lower costs and no radiation exposure, 3D sonography appears comparable to the use of CT scans and MRI in providing virtual cystoscopy in investigating bladder cancer. Virtual sonographic cystoscopy may therefore be a useful alternative for screening and follow up of tumors, particularly if conventional cystoscopy cannot be performed. However, 3D sonography cannot replace pathological staging, and there is still a need to further improve this technology for enhanced assessment of mucosal abnormalities.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
In this study, we evaluated the role of MDCTU in patients older than 50 years who presented with different types of hematuria. In a retrospective manner, we assessed the radiologic reports of 173 patients ≥50 years who underwent MDCTU as a part of the evaluation for hematuria. To estimate the accuracy of MDCTU in the detection of upper urinary tract urothelial carcinoma (UUTUC) we compared MDCTU findings with the results of ureteroscopy. We also evaluated which factors can predict ureteroscopic confirmation of MDCTU-based diagnosis. In this list we also included diabetes mellitus and anticoagulant medications. As a resu...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
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