Pharmacokinetics of levobupivacaine following infant spinal anesthesia

Summary BackgroundInfant spinal anesthesia with levobupivacaine has been promoted as a technique to reduce both the risk of postoperative apnea and exposure to volatile anesthesia. There is, however, no pharmacokinetic data to support the currently recommended doses. AimsOur aim was to determine whether infant levobupivacaine spinal anesthesia is associated with plasma concentrations consistent with a low risk of local anesthetic systemic toxicity. MethodsThis was an openā€label pharmacokinetic safety and tolerability study of levobupivacaine spinal anesthesia in infants
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Research Report Source Type: research

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ConclusionGiven our findings, conservative treatment should be compared to surgical treatment for displaced fractures and the anterior approach should be compared to the posterior one for surgical cases.Level of evidenceIV.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
ConclusionsThe absence of FUS-related histologic findings suggests that the neuromodulation and MR-ARFI protocols evaluated do not cause tissue damage.
Source: Brain Stimulation - Category: Neurology Source Type: research
ConclusionsFor the first time in humans, the present data show direct evidence in favour of a distributed system of connections from the posterior parietal cortex to the ipsilateral primary motor cortex. In addition, we show that dual cortical stimulation is a novel and efficient technique to investigate intraoperative brain connectivity in the anaesthetized patient.
Source: Brain Stimulation - Category: Neurology Source Type: research
Publication date: Available online 21 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Arnaud Meffert, Dimitri Baudrier, Dan Benhamou, Laurent Mattatia, Antonia Blanié
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
CONCLUSION: This study shows a large proportion of post-operative oesophagectomy patients do not require ICU level support, however in the absence of a reliable pre-operative predictive tool, post-operative ICU care is still required in our setting. An individualised post-operative approach could be explored to help divert stable patients, potentially up to half of the group, away from ICU. PMID: 32078601 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
New treatments involving anaesthesia drugs and neurofeedback could soon be used for getting over a breakupNothing is quite as shattering as a broken heart. A bad breakup has been known to trigger a range of psychological and physical symptoms, from nausea and insomnia to clinical depression. In more extreme scenarios,broken heart syndrome– when a person’s heart stops pumping blood properly after an emotional shock – can lead to death.Fortunately, recent breakthroughs suggest we may soon be able to beat it. In March, aSpanish study found propofol, a sedative used for anaesthesia, may also be able to mute t...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Neuroscience Relationships Psychology Life and style UK news World news Source Type: news
Conclusions: Intraoperative liposomal bupivacaine use reduced opioid use and postoperative pain for the first 24 hours after fixation of intertrochanteric femur fractures. Significant increases in likelihood of discharge to home may present an opportunity for cost savings. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusion: Retinal vascular abnormalities in the affected eyes and fundoscopically normal fellow eyes of unilateral persistent fetal vasculature patients were found in 100% and 90.0% of patients, respectively. Fellow eyes had some subtle abnormalities that were only revealed through FA. These unilateral persistent fetal vasculature cases were still bilaterally affected.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Publication date: Available online 21 February 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Viyayanand Nadella
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: 20 February 2020Source: Cell, Volume 180, Issue 4Author(s): Mototaka Suzuki, Matthew E. LarkumSummaryThe mystery of general anesthesia is that it specifically suppresses consciousness by disrupting feedback signaling in the brain, even when feedforward signaling and basic neuronal function are left relatively unchanged. The mechanism for such selectiveness is unknown. Here we show that three different anesthetics have the same disruptive influence on signaling along apical dendrites in cortical layer 5 pyramidal neurons in mice. We found that optogenetic depolarization of the distal apical dendrites cause...
Source: Cell - Category: Cytology Source Type: research
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