Pharmacokinetics of levobupivacaine following infant spinal anesthesia
ConclusionTotal plasma concentrations and unbound (free) concentration of levobupivacaine were consistently lower than concentrations reported in cases of pediatric local anesthetic toxicity. In a small number of infants requiring a repeat spinal of 1 mg·kg−1 was also associated with acceptable total and free concentrations. We conclude that levobupivacaine at 1 mg·kg−1 is associated with no systemic side effects in infants receiving awake spinal anesthesia.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Geoff Frawley, Ben Hallett, Tony Velkov, Andrew Bjorksten Tags: Research Report Source Type: research