Abstract A21: The PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by blocking the NaV1.6 sodium channel and modulating the NF-{kappa}B pathway, independently of the fusion oncoprotein

Conclusion: we show that RING1B is pivotal in ES cells, independent of the fusion oncogene, likely reflecting traits of the cell of origin.Citation Format: Inmaculada Hernandez-Muñoz, Elisabeth Figuerola, Sara Sanchez-Molina, Jaume Mora. The PRC1 protein RING1B contributes to Ewing sarcoma tumorigenesis by blocking the NaV1.6 sodium channel and modulating the NF-κB pathway, independently of the fusion oncoprotein. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr A21.

Source: Cancer Research - April 3, 2016 Category: Cancer & Oncology Authors: Hernandez–Munoz, I., Figuerola, E., Sanchez–Molina, S., Mora, J. Tags: Epigenetics Source Type: research