Cytotoxicity of chemical constituents from the roots of Knema globularia

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Uraiwan Sriphana, Chavi Yenjai, Mayrin Koatthada Two new diaryloctanes, kneglobularic acid A (1) and kneglobularic acid B (2), as well as a new acetophenone derivative, kneglobularone A (3), together with four known compounds (4–7) were isolated from the hexane extract of the roots of Knema globularia. Structures of all compounds were determined by IR, MS, 1D and 2D NMR spectroscopic methods. The crude extracts and all isolates were evaluated for cytotoxicity, and kneglobularone A (3) exhibited moderate cytotoxicity against the NCI-H187, KB and Vero cell lines with IC50 values ranging from 8.23 to 13.07μg/mL. Graphical abstract

Source: Phytochemistry Letters - April 5, 2016 Category: Chemistry Source Type: research