Clinically-applicable Monte Carlo-based biological dose optimization for the treatment of head and neck cancers with spot-scanning proton therapy

A Graphics Processor Unit (GPU)-accelerated and Monte Carlo-based Intensity Modulated Proton Therapy (IMPT) optimizer was used to escalate the biological dose (BD) in small head-and-neck tumors. Compared to conventional IMPT planning, a modest rise in target physical dose can result in a BD enhancement that is several times as large, without additional detriment to critical structures. This optimizer will be used in a feasibility trial on biological optimization, accrual starting in 2016 at our institution.

Source: International Journal of Radiation Oncology * Biology * Physics - April 4, 2016 Category: Radiology Authors: Hok Seum Wan Chan Tseung, Jiasen Ma, Cole R. Kreofsky, Daniel J. Ma, Chris Beltran Tags: Physics Contribution Source Type: research