4 Advances That Make In Vitro Fertilization More Successful Than Ever
Tanmoy Mukherjee, MD Associate Director, Division of Reproductive Endocrinology and Infertility, Mount Sinai Health System; Co-Director, Reproductive Medicine Associates of New York; Assistant Clinical Professor of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai When prospective parents who are unable to conceive a child on their own consult me for assistance, I am excited to help them build their families. But for them, dealing with the challenges of infertility can be as stressful as having cancer. Fortunately, the latest advances in in vitro fertilization (IVF) are giving them a better chance than ever of achieving their dreams. What Is In Vitro Fertilization? IVF is a medical and surgical approach to conception that involves fertilizing eggs outside a woman's body. Normally, women produce one egg per monthly menstrual cycle, but IVF requires several eggs to increase the effectiveness of each procedure. To boost egg production, women take a series of medications over the course of two weeks. Mature eggs are then retrieved during a minor surgical procedure in a physician's office, and fertilized in the laboratory with the partner's sperm. After about five days, one or two of the developing embryos are inserted into the woman's uterus or, more and more these days, biopsied, frozen, and saved for future use. IVF treats infertility caused by various factors, including damaged or blocked fallopian tubes, male problems (such as low or n...
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
We describe a case of an 80-year-old woman with ovarian metastasis of MCC six years after excision of a cutaneous MCC on the cheek.DiscussionTo our knowledge only three cases with ovarian metastasis of MCC have been described so far. Our case is the second with distant metastasis to the ovary spreading from a primary tumor in the skin of the head, in the other two cases the primary tumor was in the inguinal skin.ConculsionMCC is a highly aggressive cutaneous and mucosal malignancy with frequent recurrence, lymph node and distant metastases. There is no clear consensus how to treat metastatic disease.
Conclusion(s)Our results indicate a significant correlation among CHL1, CHL1-AS1 and CHL1-AS2, which might be involved in the development of ovarian EM and serve as novel targets for future research.
We report the delayed delivery of a second baby in a twin pregnancy with pPROM and very premature delivery of the first baby. This condition is exceptional and there are no validated medical protocols for its management; the scientific evidence is still controversial. In our case, after the birth of the first baby, pregnancy was continued for 29 days, with monitoring of maternal and fetal parameters, which enabled the delivery of the second baby with improved neonatal outcomes. This case supports the prolongation of the pregnancy of the second twin.
Abstract: Preeclampsia is a complication of pregnancy that affects approximately 4% of pregnancies. Preeclampsia is defined as new-onset hypertension after 20 weeks gestation often accompanied by new-onset proteinuria. Women who experience preeclampsia during pregnancy are at an increased risk for hypertension and stroke later in life. Healthcare providers should screen women appropriately to minimize risk.
In states that legalized medical marijuana, there was a 4.8 percent decrease in reported pain for conditions that qualified for pot treatment (cancer, arthritis, glaucoma and pain), compared to states without medical marijuana.
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