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4 Advances That Make In Vitro Fertilization More Successful Than Ever

Tanmoy Mukherjee, MD Associate Director, Division of Reproductive Endocrinology and Infertility, Mount Sinai Health System; Co-Director, Reproductive Medicine Associates of New York; Assistant Clinical Professor of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai When prospective parents who are unable to conceive a child on their own consult me for assistance, I am excited to help them build their families. But for them, dealing with the challenges of infertility can be as stressful as having cancer. Fortunately, the latest advances in in vitro fertilization (IVF) are giving them a better chance than ever of achieving their dreams. What Is In Vitro Fertilization? IVF is a medical and surgical approach to conception that involves fertilizing eggs outside a woman's body. Normally, women produce one egg per monthly menstrual cycle, but IVF requires several eggs to increase the effectiveness of each procedure. To boost egg production, women take a series of medications over the course of two weeks. Mature eggs are then retrieved during a minor surgical procedure in a physician's office, and fertilized in the laboratory with the partner's sperm. After about five days, one or two of the developing embryos are inserted into the woman's uterus or, more and more these days, biopsied, frozen, and saved for future use. IVF treats infertility caused by various factors, including damaged or blocked fallopian tubes, male problems (such as low or n...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Authors: Yılmaz Susluer S, Kayabasi C, Ozmen Yelken B, Asik A, Celik D, Balci Okcanoglu T, Serin Senger S, Biray Avci C, Kose S, Gunduz C Abstract Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in cancer development. The role of lncRNAs in hepatitis B virus (HBV) infection is not well understood. Here we analyzed the expression of 135 lncRNAs in plasm...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Health ministers call on company to lower price of cystic fibrosis drug Orkambi so the NHS can afford it.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Abstract Objective: Fecal immunochemical tests (FITs) for hemoglobin in stool are increasingly used for colorectal cancer screening. Reported sensitivities and specificities have strongly varied between studies, but it is unclear to what extent such variation reflects differences between tests or between study population characteristics. We aimed to evaluate the key parameters of FIT performance for detecting advanced neoplasia (AN) according to sex and age. Methods: Sex- and age-specific sensitivity, specificity, positive predictive values (PPVs) and negative predictive values (NPVs) for detecting AN of a qu...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research
CONCLUSION: TACE combined with partial hepatic segment thermal ablation is a safe and effective treatment for liver cancer patients, especially for those with more advanced disease. PMID: 29671661 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Applied this cycle and got rejected by every school. I had 3 interviews. Major: Neuroscience Minor: Chemistry, Public Health Country/state of residence: NC Cumulative GPA: 3.66 (currently 3.71) Science GPA: 3.49- got a C freshman year in math class (currently 3.51) Upward grade trend: 3.4 freshman year -> 3.95 senior year MCAT Scores: 130/129/130/128 Total: 517 Employment: TA for biochemistry- 10 hours a week Research: Research in cancer biology lab (paid)- 500 hours no publications or... What to do during a Gap Year
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Authors: Akatsuka S, Li GH, Toyokuni S Abstract Evolution of the species and carcinogenesis are similar in that genomic alterations are the key events. Oxidative stress derived from various etiologies is one of the major causes of carcinogenesis by inducing mutations in the genome. Persistent oxidative stress in the renal proximal tubules through Fenton reaction catalyzed by ferric nitrilotriacetate (Fe-NTA) generates renal cell carcinoma (RCC) in mice and rats. Here, in order to observe the species difference in oxidative stress-induced carcinogenesis and to obtain an insight regarding the characteristics of each ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Authors: Jasiewicz B, Sierakowska A, Jankowski W, Hoffmann M, Piorońska W, Górnicka A, Bielawska A, Bielawski K, Mrówczyńska L Abstract A series of new di- and polyamine-caffeine analogues were synthesized and characterized by NMR, FT-IR and MS spectroscopic methods. To access stability of the investigated caffeine analogues Molecular Dynamic simulations were performed in NAMD 2.9 assuming CHARMM36 force field. To evaluate the antioxidant capacity of new compounds, three different antioxidant assays were used, namely 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH•) scavenging activity, ferro...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
We describe our experience with the use of tubular retractors for accessing these deep-seated lesions. Fifty consecutive patients operated on for an intra-axial brain tumor (both biopsies and resection) from January 2016 to December 2017 by a single surgeon using tubular retractors with exoscopic visualization were prospectively identified and included in this consecutive case series. 35 patients (70%) underwent surgical resection and 15 (30%) underwent excisional biopsy for tumors located a median [interquartile range (IQR)] distance of 5.4 [4.5-6.1] cm below the cortical surface within the thalamus and/or basal ganglia i...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Source: Cancer Letters - Category: Cancer & Oncology Source Type: research
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and are poised to capture antigen, migrate to draining lymphoid organs, and postmaturation process. Recent evidences have suggested that tumor microenvironment has an effect on DCs by inactivating various components of the immune system responsible for tumor clearance, eventually leading to tumorigenesis. This inactivation is owed to the epigenetic modifications [ie, microRNA (miRNA)] at the posttranscriptional level, thus regulating the differentiation patterns and functional behavior of DCs. Thus, need of the hour is to develop protoco...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Review Article Source Type: research
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