Attenuated atrial natriuretic peptide-mediated lipolysis in subcutaneous adipocytes of obese type 2 diabetic men

Conclusions/interpretation Collectively, our data show that both ANP- and catecholamine-mediated lipolysis is attenuated in SCAT of obese men with type 2 diabetes, and might be partially explained by NP receptor defects. Therefore, improving maximal ANP responsiveness in adipose tissue might be a potential novel strategy to improve obesity-associated metabolic complications.Trial registration: ClinicalTrials.gov NCT02598544

Source: Clinical Science - April 3, 2016 Category: Biomedical Science Authors: Verboven, K., Hansen, D., Moro, C., Eijnde, B. O., Hoebers, N., Knol, J., Bouckaert, W., Dams, A., Blaak, E. E., Jocken, J. W. Tags: PublishAheadOfPrint Source Type: research